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001-es BibID:	BIBFORM057820
Első szerző:	Dóró Renáta
Cím:	Review of global rotavirus strain prevalence data from six years post vaccine licensure surveillance : is there evidence of strain selection from vaccine pressure? / Renáta Dóró, Brigitta László, Vito Martella, Eyal Leshem, Jon Gentsch, Umesh Parashar, Krisztián Bányai
Dátum:	2014
Megjegyzések:	Comprehensive reviews of pre licensure rotavirus strain prevalence data indicatedthe global importance of six rotavirus genotypes, G1P[8], G2P[4], G3P[8], G4P[8],G9P[8] and G12P[8]. Since 2006, two vaccines, the monovalent Rotarix (RV1) andthe pentavalent RotaTeq (RV5) have been available in over 100 countriesworldwide. Of these, 60 countries have already introduced either RV1 or RV5 intheir national immunization programs. Post licensure vaccine effectiveness isclosely monitored worldwide. This review aimed at describing the global changesin rotavirus strain prevalence over time. The genotype distribution of the nearly47,000 strains that were characterized during 2007-2012 showed similar picture tothat seen in the preceding period. An intriguing finding was the transientpredominance of heterotypic strains, mainly in countries using RV1. Unusual andnovel antigen combinations continue to emerge, including some causing localoutbreaks, even in vaccinated populations. In addition, vaccine strains have beenfound in both vaccinated infants and their contacts and there is evidence forgenetic interaction between vaccine and wild-type strains. In conclusion, thepost-vaccine introduction strain prevalence data do not show any consistentpattern indicative of selection pressure resulting from vaccine use, although theincreased detection rate of heterotypic G2P[4] strains in some countriesfollowing RV1 vaccination is unusual and this issue requires further monitoring.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Genotype RotaTeq Rotarix Rotavirus Surveillance
Megjelenés:	Infection Genetics and Evolution. - 28 (2014), p. 446-461. -
További szerzők:	László Brigitta (1983-) (molekuláris biológus, mikrobiológus) Martella, Vito Leshem, Eyal Gentsch, Jon R. Parashar, Umesh D. Bányai Krisztián (virológus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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