Találati lista | Tudóstér

001-es BibID:	BIBFORM058217
Első szerző:	Wartiovaara, Ulla
Cím:	Effect of Val34Leu polymorphism on the activation of the coagulation factor XIII-A / U. Wartiovaara, H. Mikkola, G. Szőke, G. Haramura, L. Kárpáti, I. Balogh, R. Lassila, L. Muszbek, A. Palotie
Dátum:	2000
ISSN:	0340-6245
Megjegyzések:	Coagulation factor XIII (FXIII) is a protransglutaminase involved in the last step of the coagulation cascade by stabilising the fibrin clot. Recently, a common variation (FXIII Val34Leu) has been associated with a decreased risk of myocardial infarction and deep venous thrombosis. Val34Leu is critically located near the thrombin activation site of FXIII-A. In this study we investigated its effects on the activation of FXIII. Both recombinant and platelet-derived FXIII Val34Leu variants were shown to be more susceptible to thrombin cleavage than the wild type FXIII. The rate of enzymatic activation of FXIII Val34Leu was found increased, however, the specific activity of fully activated wild type FXIII and the Val34Leu mutant did not differ. During the course of thrombin-induced activation of FXIII fibrin gamma-chain dimerisation and alpha-chain polymerisation developed more rapidly with the Val34Leu mutant. The increased rate of fibrin stabilisation brought about by the Val34Leu FXIII seems to be paradoxically associated with a protective effect against pathological thrombosis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Factor XIII Factor XII Val34Leu thrombin peptide
Megjelenés:	Thrombosis and Haemostasis. - 84 : 4 (2000), p. 595-600. -
További szerzők:	Mikkola, Hanna Szőke Gabriella Haramura Gizella (1957-) (vezető analitikus) Kárpáti L. Balogh István (1972-) (molekuláris biológus, genetikus) Lassila, Riitta Muszbek László (1942-) (haematológus, kutató orvos) Palotie, Aarno
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: