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001-es BibID:	BIBFORM059412
Első szerző:	Zolberg, Relevy Noa
Cím:	Vitamin A-Deficient Diet Accelerated Atherogenesis in Apolipoprotein E-/- Mice and Dietary [betan]-Carotene Prevents This Consequence/ Relevy Noa Zolberg, Harats Dror, Harari Ayelet, Ben-Amotz Ami, Bitzur Rafael, Rühl Ralph, Shaish Aviv
Dátum:	2015
ISSN:	2314-6133 2314-6141
Megjegyzések:	Vitamin A is involved in regulation of glucose concentrations, lipidmetabolism, and inflammation, which are major risk factors for atherogenesis. However, the effect of vitamin A deficiency on atherogenesis has not been investigated. Therefore, the objective of the current study was to examine whether vitamin A deficiency accelerates atherogenesis in apolipoprotein E-deficient mice (apoE(-/-)). ApoE(-/-) mice were allocated into the following groups: control, fed vitamin A-containing chow diet; BC, fed chow diet fortified with Dunaliella powder containing beta c isomers; VAD, fed vitamin A-deficient diet; and VAD-BC group, fed vitamin A-deficient diet fortified with a Dunaliella powder. Following 15 weeks of treatment, liver retinol concentration had decreased significantly in the VAD group to about 30% that of control group. Vitamin A-deficient diet significantly increased both plasma cholesterol concentrations and the atherosclerotic lesion area at the aortic sinus (+61%) compared to the control group. Dietary beta c fortification inhibited the elevation in plasma cholesterol and retarded atherogenesis in mice fed the vitamin A-deficient diet. The results imply that dietary vitamin A deficiency should be examined as a risk factor for atherosclerosis and that dietary beta c, as a sole source of retinoids, can compensate for vitamin A deficiency.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban RETINOL-BINDING-PROTEIN ALGA DUNALIELLA-BARDAWIL LIPID-METABOLISM KNOCKOUT MICE RAT AORTA LIVER RECEPTOR CELLS ACID EXPRESSION
Megjelenés:	Biomed Research International. - 2015 (2015), p. 1-9. -
További szerzők:	Harats, Dror Harari, Ayelet Ben-Amotz, Ami Bitzur, Rafael Rühl, Ralph (1969-) (vegyész) Shaish, Aviv
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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