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001-es BibID:	BIBFORM059434
Első szerző:	Bodoki Levente (PhD hallgató)
Cím:	Vitamin D Receptor Gene Polymorphisms and Haplotypes in Hungarian Patients with Idiopathic Inflammatory Myopathy / Bodoki Levente, Chen Ji-Qing, Zeher Margit, Nagy-Vincze Melinda, Griger Zoltán, Zilahi Erika, Dankó Katalin
Dátum:	2015
ISSN:	2314-6133 2314-6141
Megjegyzések:	Idiopathic inflammatory myopathies are autoimmune diseases characterized by symmetrical proximal muscle weakness. Our aim was to identify a correlation between VDR polymorphisms or haplotypes and myositis. We studied VDR-BsmI, VDR-ApaI, VDR-TaqI, and VDR-FokI polymorphisms and haplotypes in 89 Hungarian poly-/dermatomyositis patients (69 females) and 93 controls (52 females). We did not obtain any significant differences for VDR-FokI, BsmI, ApaI, and TaqI genotypes and allele frequencies between patients withmyositis and healthy individuals. There was no association of VDR polymorphisms with clinical manifestations and laboratory profiles inmyositis patients. Menwithmyositis had a significantly different distribution of BB, Bb, and bb genotypes than female patients, control male individuals, and the entire control group. Distribution of TT, Tt, and tt genotypes was significantly different inmales than in females in patient group. According to four-marker haplotype prevalence, frequencies of sixteen possible haplotypes showed significant differences between patient and control groups. The three most frequent haplotypes in patients were the fbAt, FBaT, and fbAT. Our findings may reveal that there is a significant association: Bb and Tt genotypes can be associated with myositis in the Hungarian population we studied. We underline the importance of our result in the estimated prevalence of four-marker haplotypes
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban BONE-MINERAL DENSITY RHEUMATOID-ARTHRITIS MULTIPLE-SCLEROSIS BSMI POLYMORPHISM VDR GENE RISK METAANALYSIS ASSOCIATION POPULATION ALLELES
Megjelenés:	Biomed Research International. - 2015 (2015), p. 1-8. -
További szerzők:	Chen, Ji-Qing Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Nagy-Vincze Melinda (1985-) (orvos) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Zilahi Erika (1964-) (molekuláris biológus) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus)
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