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001-es BibID:	BIBFORM059613
Első szerző:	Pethő Zsófia (reumatológus, immunológus)
Cím:	Vitamin D status in men with psoriatic arthritis : a case-control study / Z. Petho, E. Kulcsar-Jakab, E. Kalina, A. Balogh, A. Pusztai, K. Gulyas, A. Horvath, Z. Szekanecz, H. P. Bhattoa
Dátum:	2015
ISSN:	0937-941X
Megjegyzések:	Summary: We determined hypovitaminosis D prevalence inmen with psoriatic arthritis. This is a cross-sectional, analystblinded, age- and sex-matched, case-control study. Men withpsoriatic arthritis have significantly lower 25-hydroxyvitaminD levels. Men with psoriatic arthritis are at increased odds ofsuffering from hypovitaminosis D.Introduction: Skeletal manifestations as a result of abruptedbone metabolism may be predominant in psoriatic arthritis(PsA). Vitamin D plays a vital role in maintenance of skeletalhealth and is known to modulate the immune system in variousautoimmune diseases including PsA. The aim of the presentstudy was to determine the prevalence of hypovitaminosisD in a treatment naïve, de novo psoriatic arthritis male cohortin a cross-sectional, analyst blinded, age- and sex-matched,case-control study.Methods: 25 hydroxyvitamin D (25OHD), parathyroid (PTH),osteocalcin (OC) and C-terminal telopeptides of type-I collagen(CTx) levels, and lumbar spine and femoral neck bonemineral density were compared between 53 PsA and controls.Results: The prevalence of hypovitaminosis D (25hydroxyvitamin D (25OHD) levels <75 nmol/L) was 81 and57 % in the PsA and control groups, respectively. Comparedto the healthy controls, 25OHD (67.2 (12?137) nmol/L vs.51.9 (15?95) nmol/L; p=0.001) was significantly lower, andosteocalcin (13.6 (5?33) ?g/L vs. 18.2 (6?35) ?g/L; p=0.003)and C-terminal telopeptides of type-I collagen (0.20 (0.01?0.71) ?g/L vs. 0.28 (0.06?0.69) ?g/L; p=0.008) were significantlyhigher in the PsA group. A significant association wasfound between hypovitaminosis D and PsA; the odds for patientswith PsA of having hypovitaminosis D was 3.297 (95%confidence interval 1.372 to 7.922).Conclusion: The results of this study suggest that men withPsA have significantly lower 25-hydroxyvitamin D levels,and furthermore, men with PsA are at statistically significantincreased odds of suffering from hypovitaminosis D.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban bone markers bone mineral density men psoriatic arthritis vitamin D
Megjelenés:	Osteoporosis International. - 26 : 7 (2015), p. 1965-1970. -
További szerzők:	Jakab Éva (1969-) Kalina Edit (1971-) (laboratóriumi analitikus) Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos) Karancsiné Pusztai Anita (1989-) (tudományos segédmunkatárs) Gulyás Katalin (reumatológus) Horváth Ágnes (1985-) (reumatológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos)
Pályázati támogatás:	OTKA-105073 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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