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001-es BibID:	BIBFORM060688
Első szerző:	Chen, Ji-Qing
Cím:	Toll-Like Receptor Pathways in Autoimmune Diseases / Ji-Qing Chen, Peter Szodoray, Margit Zeher
Dátum:	2016
ISSN:	1080-0549
Megjegyzések:	Autoimmune diseases are a family of chronic systemic inflammatory disorders, characterized by the dysregulation of the immune system which finally results in the break of tolerance to self-antigen. Several studies suggest that Toll-like receptors (TLRs) play an essential role in the pathogenesis of autoimmune diseases. TLRs belong to the family of pattern recognition receptors (PRRs) that recognize a wide range of pathogen-associated molecular patterns (PAMPs). TLRs are type I transmembrane proteins and located on various cellular membranes. Two main groups have been classified based on their location; the extracelluar group referred to the ones located on the plasma membrane while the intracellular group all located in endosomal compartments responsible for the recognition of nucleic acids. They are released by the host cells and trigger various intracellular pathways which results in the production of proinflammatory cytokines, chemokines, as well as the expression of co-stimulatory molecules to protect against invading microorganisms. In particular, TLR pathway-associated proteins, such as IRAK, TRAF, and SOCS, are often dysregulated in this group of diseases. TLR-associated gene expression profile analysis together with single nucleotide polymorphism (SNP) assessment could be important to explain the pathomechanism driving autoimmune diseases. In this review, we summarize recent findings on TLR pathway regulation in various autoimmune diseases, including Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), multiple sclerosis (MS), rheumatoid arthritis (RA), systemic sclerosis (SSc), and psoriasis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Toll-like receptors (TLRs) Autoimmune disease IL-1-receptor-associated kinase (IRAK) TNF-receptor-associated factor (TRAF) Suppressor of cytokine signaling (SOCS)
Megjelenés:	Clinical Reviews In Allergy & Immunology 50 : 1 (2016), p. 1-17. -
További szerzők:	Szodoray Péter (1973-) (belgyógyász, orvos) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Pályázati támogatás:	TÁMOP-4.2.2.A-11/1/KONV-2012-0023 TÁMOP
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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