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001-es BibID:	BIBFORM061059
Első szerző:	Maccarrone, Mauro
Cím:	Endocannabinoid signaling at the periphery : 50 years after THC / Mauro Maccarrone, Itai Bab, Tamás Bíró, Guy A. Cabral, Sudhansu K. Dey, Vincenzo Di Marzo, Justin C. Konje, George Kunos, Raphael Mechoulam, Pal Pacher, Keith A. Sharkey, Andreas Zimmer
Dátum:	2015
ISSN:	0165-6147
Megjegyzések:	In 1964, the psychoactive ingredient of Cannabis sativa,D9-tetrahydrocannabinol (THC), was isolated. Nearly30 years later the endogenous counterparts of THC, col-lectively termed endocannabinoids (eCBs), were discov-ered: N-arachidonoylethanolamine (anandamide) (AEA)in 1992 and 2-arachidonoylglycerol (2-AG) in 1995. Sincethen, considerable research has shed light on the impactof eCBs on human health and disease, identifying anensemble of proteins that bind, synthesize, and degradethem and that together form the eCB system (ECS). eCBscontrol basic biological processes including cell choicebetween survival and death and progenitor/stem cellproliferation and differentiation. Unsurprisingly, in thepast two decades eCBs have been recognized as keymediators of several aspects of human pathophysiologyand thus have emerged to be among the most widespreadand versatile signaling molecules ever discovered. Heresome of the pioneers of this research field review the stateof the art of critical eCB functions in peripheral organs. Ourcommunity effort is aimed at establishing consensusviews on the relevance of the peripheral ECS for humanhealth and disease pathogenesis, as well as highlightingemerging challenges and therapeutic hopes.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban bone cardiovascular system gastrointestinal tract immune system liver localization muscle female and male reproductive system signaling pathways skin
Megjelenés:	Trends In Pharmacological Sciences. - 36 : 5 (2015), p. 277-296. -
További szerzők:	Bab, Itai Bíró Tamás (1968-) (élettanász) Cabral, Guy A. Dey, Sudhansu K. Di Marzo, Vincenzo Konje, Justin C. Kunos, George Mechoulam, Raphael Pacher Pál Sharkey, Keith A. Zimmer, Andreas
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