Találati lista | Tudóstér

001-es BibID:	BIBFORM061109
Első szerző:	Balog Márta
Cím:	Sex-specific chronic stress response at the level of adrenal gland modifies sexual hormone and leptin receptors / Marta Balog, Milan Miljanović, Senka Blažetić, Irena Labak, Vedrana Ivić, Barbara Viljetić, Attila Borbely, Zoltán Papp, Robert Blažeković, Sandor G. Vari, Miklós Fagyas, Marija Heffer
Dátum:	2015
ISSN:	0353-9504
Megjegyzések:	AimTo compare cardiometabolic risk-related biochemical markers and sexual hormone and leptin receptors in the adrenal gland of rat males, non-ovariectomized females (NON-OVX), and ovariectomized females (OVX) under chronic stress.MethodsForty six 16-week-old Sprague-Dawley rats were divided into male, NON-OVX, and OVX group and exposed to chronic stress or kept as controls. Weight, glucose tolerance test (GTT), serum concentration of glucose, and cholesterol were measured. Adrenal glands were collected at the age of 28 weeks and immunohistochemical staining against estrogen beta (ER?), progesterone (PR), testosterone (AR), and leptin (Ob-R) receptors was performed.ResultsBody weight, GTT, serum cholesterol, and glucose changed in response to stress as expected and validated the applied stress protocol. Stressed males had significantly higher number of ER? receptors in comparison to control group (P?=?0.028). Stressed NON-OVX group had significantly decreased AR in comparison to control group (P?=?0.007). The levels of PR did not change in any consistent pattern. The levels of Ob-R increased upon stress in all groups, but the significant difference was reached only in the case of stressed OVX group compared to control (P?=?0.033).ConclusionChronic stress response was sex specific. OVX females had similar biochemical parameters as males. Changes upon chronic stress in adrenal gland were related to a decrease in testosterone receptor in females and increase in estrogen receptor in males.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban chronic stress Leptin sexual hormone
Megjelenés:	Croatian Medical Journal. - 56 : 2 (2015), p. 104-113. -
További szerzők:	Miljanović, Milan Blažetić, Senka Labak, Irena Ivić, Vedrana Viljetić, Barbara Borbély Attila (1978-) (kardiológus) Papp Zoltán (1965-) (kardiológus, élettanász) Blazeković, Robert Vári Sándor G. Fagyas Miklós (1984-) (orvos) Heffer, Marija
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: