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001-es BibID:	BIBFORM061229
Első szerző:	Miltényi Zsófia (belgyógyász, haematológus)
Cím:	Prognostic value of interim and restaging PET/CT in Hodgkin lymphoma : results of the CHEAP (Chemotherapy Effectiveness Assessment by PET/CT) study - long term observation. / Z. Miltenyi, S. Barna, I. Garai, Z. Simon, A. Jona, F. Magyari, L. Gergely, Z. Nagy, K. Keresztes, P. Pettendi, A. Illes
Dátum:	2015
Megjegyzések:	Very few studies have determined the prognostic value of interim and restaging PET/CT in patients with Hodgkin lymphoma using current standard of care therapy outside clinical trials. We analyzed the effect of the results of interim and restaging PET/CT on the survival (overall- and relapse-free) in patients who received standard first-line treatment based on the stage of disease and risk factors. We investigated the differences between the relapse and non-relapse groups based on the clinical pathological characteristics of patients who had positive interim PET/CT results. Between January 1, 2007 and December 31, 2011, the staging, interim and restaging PET/CT scans of patients with Hodgkin lymphoma were analyzed. The Deauville criteria were used for the evaluation of interim PET/CT scans. One hundred and thirteen Hodgkin lymphoma patients underwent staging, interim and restaging PET/CT scans. None of the therapy was modified based on the interim PET/CT results. The median follow-up time was 43.5 months. A total of 62 early stage patients and 51 advanced stage patients were identified. The five-year overall survival rates were 93.4% in the interim PET negative group and 58% in the interim PET positive group (p<0.001). The five-year relapse-free survival rates for the negative and positive groups were 92.7% and 40.8%, respectively (p<0.001). The negative predictive value was 100% in the early stage group and 82.35% in the advanced stage group. By comparison, the positive predictive values were 53.8% and 58.8%, respectively, in these two groups. In the interim PET positive group, patients over 40 years of age had a significantly higher probability of relapse (p=0.057). The routine clinical use of interim PET/CT is highly recommended based on our investigation. However, patients with positive interim PET/CT results required frequent additional evaluations.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban predictive value Hodgkin lymphoma PET/CT
Megjelenés:	Neoplasma. - 62 : 4 (2015), p. 627-34. -
További szerzők:	Barna Sándor (1982-) (kutató orvos) Garai Ildikó (1966-) (radiológus) Simon Zsófia (1977-) (belgyógyász, haematológus) Jóna Ádám (1985-) (belgyógyász, hematológus) Magyari Ferenc (1985-) (belgyógyász, hematológus) Gergely Lajos (1965-) (belgyógyász, haematológus) Nagy Z. Keresztes Katalin Pettendi Piroska Illés Árpád (1959-) (belgyógyász, haematológus, onkológus)
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