Találati lista | Tudóstér

001-es BibID:	BIBFORM062454
Első szerző:	Moore, Richard A.
Cím:	Dexketoprofen/tramadol 25 mg/75 mg : randomised double-blind trial in moderate-to-severe acute pain after abdominal hysterectomy / R. A. Moore, H. J. McQuay, J. Tomaszewski, G. Raba, D. Tutunaru, N. Lietuviete, J. Galad, L. Hagymasy, D. Melka, J. Kotarski, T. Rechberger, B. Fülesdi, A. Nizzardo, C. Guerrero-Bayón, S. Cuadripani, B. Pizà-Vallespir, M. Bertolotti
Dátum:	2016
ISSN:	1471-2253
Megjegyzések:	Background: Dexketoprofen trometamol plus tramadol hydrochloride is a new oral combination of two analgesics, which have different mechanisms of action for the treatment of moderate to severe acute pain. Methods: Randomised, double-blind, parallel, placebo and active-controlled, single and multiple-dose study to evaluate the analgesic efficacy and safety of dexketoprofen/tramadol 25 mg/75 mg in comparison with the single agents (dexketoprofen 25 mg and tramadol 100 mg) in moderate to severe acute pain after abdominal hysterectomy. Results: The efficacy analysis included 606 patients, with a mean age of 48 years (range 25-73). The study results confirmed the superiority of the combination over the single agents in terms of the primary endpoint (p <0.001). Secondary endpoints were generally supportive of the superiority of the combination for both single and multiple doses. Conclusions: The study results provided robust evidence of the superiority of dexketoprofen/tramadol 25 mg/75 mg over the single components in the management of moderate to severe acute pain, as confirmed by the single-dose efficacy, repeated-dose sustained effect and good safety profile observed. Trial registration: EU Clinical Trials Register (EudraCT number 2012-004545-32 , registered 04 October 2012); Clinicaltrials.gov ( NCT01904149 , registered 17 July 2013). ? 2016 Moore et al.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Analgesics Dexketoprofen trometamol Drug combinations Hysterectomy Pain Postoperative Tramadol
Megjelenés:	BMC Anesthesiology 16 : 1 (2016), p. 1-14. -
További szerzők:	McQuay, H. J. Tomaszewski, J. Raba, G. Tutunaru, D. Lietuviete, N. Galad, J. Hagymasy, L. Melka, D. Kotarski, J. Rechberger, Tomasz Fülesdi Béla (1961-) (aneszteziológus) Nizzardo, A. Guerrero-Bayón, C. Cuadripani, S. Pizà-Vallespir, B. Bertolotti, M.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: