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001-es BibID:	BIBFORM063573
035-os BibID:	(WoS)000370879300017 (Scopus)84960127994
Első szerző:	Kovac, Mirjana
Cím:	Pregnancy related stroke in the setting of homozygous type-II HBS antithrombin deficiency / Mirjana Kovac, Gorana Mitic, Zeljko Mikovic, Valentina Djordjevic, László Muszbek, Zsuzsanna Bereczky
Dátum:	2016
ISSN:	0049-3848
Megjegyzések:	Dear Editors,Stroke is defined as a focal or global disturbance of cerebral functionlasting over 24 h; resulting from disruption of blood supply [1]. Strokeduring pregnancy is fortunately a rare event, but it can have severe consequences,such as long-termdisability or death,with 9.5% of allmaternaldeaths being related to stroke [2]. The overall risk of pregnancyrelatedstroke was 34.2 (95% CI 33.3?35.1) per 100 000 deliveries inthe USA, with 48% occurring postpartum, 41% at the time of deliveryand 11% antepartum [3]. The physiological changes of pregnancycould be connected with increased stroke risk, while several specificmedical conditions, including hypertensive disorders, obesity andheart disease, additionally increase it [1].Moreover, patient risk factors,like a hypercoagulable state and preeclampsia, also need to be takeninto account. Data from an earlier study [3] showed that thrombophiliais strongly associated with stroke, indicating an OR of 16 (CI 9.4?27.2).Inherited antithrombin (AT) deficiency is a rare autosomal dominantdisorder, caused bymutation in SERPINC1. So far, over 250 differentmutations leading to AT deficiency have been reported [4]. It is classifiedinto two types; type-I is a quantitative disorder characterized by bothdecreased antigen amount and activity, while type-II is a functional disorderclassified into three subtypes according to the site of the causativemutations [5]. Unlike other forms of AT deficiency, type-II HBS representsa minor thrombotic risk in its heterozygous form, while homozygoustype-II HBS AT deficiency is characterized by early onset of arterialand venous thrombosis [6].
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk type-II HBS antithrombin deficiency Pregnancy Stroke
Megjelenés:	Thrombosis Research. - 139 (2016), p. 111-113. -
További szerzők:	Mitic, Gorana Mikovic, Zeljko Djordjevic, Valentina Muszbek László (1942-) (haematológus, kutató orvos) Bereczky Zsuzsanna (1974-) (orvosi laboratóriumi diagnosztika szakorvos)
Pályázati támogatás:	PD101120 OTKA K116228 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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