Találati lista | Tudóstér

001-es BibID:	BIBFORM063680
Első szerző:	Whitfield, David
Cím:	Depression and Synaptic Zinc Regulation in Alzheimer Disease, Dementia with Lewy Bodies, and Parkinson Disease Dementia / David R. Whitfield, Julie Vallortigara, Amani Alghamdi, Tibor Hortobágyi, Clive Ballard, Alan J. Thomas, John T. O'Brien, Dag Aarsland, Paul T. Francis
Dátum:	2015
ISSN:	1064-7481
Megjegyzések:	OBJECTIVE:Depression is a common symptom in dementia with Lewy bodies (DLB), Parkinson disease dementia (PDD), and Alzheimer disease (AD), yet its molecular basis remains unclear and current antidepressants do not appear to be effective. Cerebral zinc has been implicated in depression and synaptic dysfunction. We investigated the relationship between synaptic zinc regulation (for which zinc transporter 3 [ZnT3] is responsible) and depression in a large clinicopathologic study.METHODS:We examined brains from people with PDD (N = 29), DLB (N = 27), and AD (N = 15) and comparison subjects without depression or dementia (N = 24). Individuals were categorized according to the presence and severity of depression (on a scale of 0-3) based on standardized assessments during life (principally Neuropsychiatric Inventory). Western blotting was used to determine ZnT3 levels in Brodmann area 9 (BA9), and regression analysis was used to determine the relationship between ZnT3 and depression.RESULTS:Reductions in ZnT3 in BA9 were significantly associated with elevated depression scores in the study cohort (? = -0.351, df = 93, t = -3.318 p = 0.0004). This association remained when only individuals with DLB, PDD, and no dementia or depression were examined (? = -0.347, df = 78, t = -3.271, p = 0.002) or only individuals with AD and no dementia or depression were examined (? = -0.433, df = 37, t = -2.924, p = 0.006).CONCLUSION:Although decreased zinc levels have been implicated in the genesis of depression in animal models and in major depressive disorder in humans, this study provides the first evidence of a role for zinc in depression in people with dementia and highlights zinc metabolism as a therapeutic target.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Depression Alzheimer disease Lewy body dementia Parkinson disease dementia zinc
Megjelenés:	American Journal Of Geriatric Psychiatry. - 23 : 2 (2015), p. 141-148. -
További szerzők:	Vallortigara, Julie Alghamdi, Amani Hortobágyi Tibor (1965-) (patológus) Ballard, Clive G. Thomas, Alan O'Brien, John Aarsland, Dag Francis, Paul T.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: