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001-es BibID:	BIBFORM064133
Első szerző:	Nemes Balázs Áron (sebész)
Cím:	Can a Cutoff Value for Cystatin C in the Operative Setting Be Determined to Predict Kidney Function After Liver Transplantation? / B. Nemes, G. Zádori, F. Gelley, G. Gámán, D. Görög, A. Doros, E. Sárváry
Dátum:	2010
ISSN:	0041-1345
Megjegyzések:	Correct assessment and follow-up of kidney function is essential in liver transplantrecipients. Glomerular filtration rate (GFR) represents the functional capacity of thekidney. The GFR is generally determined on the basis of creatinine clearance using severalmethods. It has been suggested that cystatin C be used rather than GFR. Production ofcystatin C is not dependent on the same factors as creatinine. It is filtered and completelymetabolized in the glomeruli, and is not secreted by the kidney tubules. The objective ofthis study was to determine a preoperative cutoff value for cystatin C based on kidneyfunction estimated after liver transplantation. At prefixed times before and after orthotopicliver transplantation (OLT), serum cystatin C and creatinine concentrations weremeasured, and GFR was calculated using the Cockroft-Gault equation. Patients weredivided into 2 groups according to GFR on postoperative days 1 to 5. Group 1 (healthyrecipients) included patients with post-OLT GFR greater than 70 mL/min; and group 2(kidney-impaired recipients), post-OLT GFR less than 70 mL/min. Group 2 demonstratedgreater risk of postoperative complications, abnormal postoperative creatinine concentrationsand GFR values, and worse patient and graft survival. Based on the preoperativecystatin C concentration, postoperative kidney function can be assessed. The cutoff valuefor preoperative cystatin was determined using receiver operating characteristics analysis.When the preoperative cystatin C concentration exceeded 1.28 mg/L, the postoperativeGFR was less than 70 mL/min in the first 5 days after OLT. These findings suggest that ifthe cystatin C concentration exceeds the cutoff point preoperatively, there will bedeterioration of kidney function after OLT. Along with other researchers, we suggest thatcystatin C is a sensitive marker of post-OLT kidney function.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Transplantation Proceedings 42 : 6 (2010), p. 2323-2326. -
További szerzők:	Zádori Gergely (1983-) (sebész) Gelley Fanni Gámán György Görög Dénes Doros Attila Sárváry Enikő
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