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001-es BibID:	BIBFORM064237
Első szerző:	Gelley Fanni
Cím:	MicroRNA profile before and after antiviral therapy in liver transplant recipients for hepatitis C virus cirrhosis / Fanni Gelley, Gergely Zadori, Balazs Nemes, Matteo Fassan, Gabor Lendvai, Eniko Sarvary, Attila Doros, Zsuzsanna Gerlei, Peter Nagy, Zsuzsa Schaff, Andras Kiss
Dátum:	2014
Megjegyzések:	Background and Aim: Management of hepatitis C virus (HCV) recurrence is a majorchallenge after liver transplantation. Significant dysregulated expression of HCV receptors(i.e. claudin-1, occludin, tetraspanin CD81, scavenger receptor type B1) has been shownrecently during HCV infection. This might facilitate hepatocytic entry and reinfection ofHCV. MicroRNAs (miRs) play role in the regulation of gene expression. We aimedto characterize miR expression profiles related to HCV infection and antiviral therapy inadult liver transplant recipients, with special emphasis on miRs predicted to target HCVreceptors.Methods: Twenty-eight adult liver transplant recipients were enrolled in the study. Pairedbiopsies were obtained at the time of HCV recurrence and at the end of antiviral treatment.MiRs for HCV receptors were selected using target prediction software. Expression levelsof miR-21, miR-23a miR-34a, miR-96, miR-99a, miR-122, miR-125b, miR-181a-2,miR-194, miR-195, miR-217, miR-221, and miR-224 were determined by reversetranscription?quantitative polymerase chain reaction.Results: miR-99a* and miR-224 expressions were increased in HCV recurrence samples,while miR-21 and miR-194 were decreased in comparison to normal liver tissue. Increasedexpressions of miR-221, miR-224, and miR-217 were observed in samples taken afterantiviral therapy when compared with HCV recurrence samples. High HCV titer at recurrencewas associated with higher level of miR-122.Conclusions: Samples at recurrence of HCV and after antiviral therapy revealed distinctHCV-related miR expression profiles, with significant dysregulation of those miRNAspotentially targeting mRNAs of HCV receptors. In particular, miR-194 and miR-21 mightbe involved in the regulation of HCV receptor proteins' expression during HCV infectionand antiviral therapy.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban HCV receptors HCV liver transplantation microRNA SVR
Megjelenés:	Journal of gastroenterology and hepatology. - 29 : 1 (2014), p. 121-127. -
További szerzők:	Zádori Gergely (1983-) (sebész) Nemes Balázs Áron (1969-) (sebész) Fassan, Matteo Lendvai Gábor Sárváry Enikő Doros Attila Gerlei Zsuzsa Nagy Péter Schaff Zsuzsa Kiss András
Pályázati támogatás:	OTKA K101435 OTKA
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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