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001-es BibID:	BIBFORM064520
Első szerző:	Ghassemi-Nejad, Sheida (fogorvos)
Cím:	Development of temporomandibular joint arthritis : the use of animal models / Sheida Ghassemi Nejad, Tamás Kobezda, Ildikó Tar, Zoltán Szekanecz
Dátum:	2017
ISSN:	1297-319X 1778-7254
Megjegyzések:	Osteoarthritis is the most common joint disease affecting roughly one sixth of the human population. It isalso the most common arthritis affecting the temporomandibular joint, often leading to severe pain andthe inability to masticate. Animal models are essential to investigate the disease in part because they lendthemselves to genetic manipulation and various treatments and also because of the lack of availabilityof human specimens from various stages of the disease. The wide range of osteoarthritis models aloneare a proof of its multifactorial origin. Manipulation of collagen, cytokine, matrix metalloproteinase andsmall leucine-rich repeat proteoglycan genes can all have an effect on the development and persistenceof arthritis. Surgical models also exist, highlighting the importance of normal anatomy and trauma. Herewe review the English literature of murine models of temporomandibular joint arthritis with specialattention to the genetic and molecular background of osteoarthritis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Arthritis Temporomandibular joint Animal models Murine model
Megjelenés:	Joint Bone Spine 84 : 2 (2017), p. 145-151. -
További szerzők:	Kobezda Tamás (1983-) (Ph.D hallgató) Tar Ildikó (1967-) (fogszakorvos) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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