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001-es BibID:	BIBFORM065094
Első szerző:	Viski Sándor Zsolt (orvos)
Cím:	The acute effects of alcohol on cerebral hemodynamic changes induced by the head-up tilt test in healthy subjects / Sandor Viski, Miklos Orosz, Katalin Reka Czuriga-Kovacs, Maria Tunde Magyar, Laszlo Csiba, Laszlo Olah
Dátum:	2016
ISSN:	0022-510X
Megjegyzések:	Background: Alcohol is a known triggering factor for orthostatic dysfunction, increasing the risk of neurally-mediated syncope. Since orthostatic tolerance may be affected by both systemic and cerebral hemodynamic changes, our aim was to investigate the acute effects of alcohol on cerebral vasoreactivity measured during the head-up tilt (HUT) test in 20 healthy subjects.Methods: Mean arterial blood pressure (mBP), heart rate, and flow parameters in both middle cerebral arteries (MCAs) were continuously recorded in the supine and during a 10-minute HUT positions before and after alcohol intake.Results: The HUT test resulted in a more prominent decline of adjusted mBP at the level of MCAs (mBPMCA) and a significantly larger decrease of MCA mean flow velocities (MFVMCA) in the post-alcohol period than before alcohol intake. During the HUT phase, the relative decrease in MFVMCA was significantly smaller than the reduction in mBPMCA before drinking alcohol, while these changes were similar after alcohol ingestion. The cerebrovascular resistance index (CVRi) decreased during the HUT phase in the control period, however, it increased after alcohol intake.Conclusion: The similar decrease inmBPMCA and MFVMCA during orthostatic stress after alcohol ingestion together with the increased CVRi indicated the impairment of the compensatory vasodilation of cerebral resistance vessels, i.e. impaired cerebral autoregulation. These findings suggest that alcohol may contribute to impaired orthostatic tolerance not only by a hypotensive response but also by the alteration of cerebral blood flow regulation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Alcohol Orthostatic stress Head-up tilt test Cerebral blood flow Cerebral autoregulation Baroreceptor reflex Transcranial doppler
Megjelenés:	Journal Of The Neurological Sciences. - 368 (2016), p. 113-120. -
További szerzők:	Orosz Miklós Czuriga-Kovács Katalin Réka (1981-) (neurológus) Magyar Mária Tünde (1970-) (neurológus) Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
Pályázati támogatás:	NAP_13-1-2013-0001 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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