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001-es BibID:	BIBFORM065211
Első szerző:	Szelényi Zsuzsanna
Cím:	Inflammation and oxidative stress caused by nitric oxide synthase uncoupling might lead to left ventricular diastolic and systolic dysfunction in patients with hypertension / Zsuzsanna Szelényi, Ádám Fazakas, Gábor Szénási, Melinda Kiss, Narcis Tegze, Bertalan Csaba Fekete, Eszter Nagy, Imre Bodó, Bálint Nagy, Attila Molvarec, Attila Patócs, Lilla Pepó, Zoltán Prohászka, András Vereckei
Dátum:	2015
ISSN:	1671-5411
Megjegyzések:	OBJECTIVE:To investigate the role of oxidative stress, inflammation, hypercoagulability and neuroendocrine activation in the transition of hypertensive heart disease to heart failure with preserved ejection fraction (HFPEF).METHODS:We performed echocardiography for 112 patients (? 60 years old) with normal EF (18 controls and 94 with hypertension), and determined protein carbonylation (PC), and tetrahydrobiopterin (BH4), C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-? (TNF-?), fibrinogen, plasminogen activator inhibitor type-I (PAI-I), von Willebrand factor, chromogranin A (cGA) and B-type natriuretic peptide (BNP) levels from their blood samples.RESULTS:We found that 40% (38/94) of the patients with hypertension (HT) had no diastolic dysfunction (HTDD-), and 60% (56/94) had diastolic dysfunction (HTDD+). Compared to the controls, both patient groups had increased PC and BH4, TNF-?, PAI-I and BNP levels, while the HTDD+ group had elevated cGA and CRP levels. Decreased atrial and longitudinal left ventricular (LV) systolic and diastolic myocardial deformation (strain and strain rate) was demonstrated in both patient groups versus the control. Patients whose LV diastolic function deteriorated during the follow-up had elevated PC and IL-6 level compared to their own baseline values, and to the respective values of patients whose LV diastolic function remained unchanged. Oxidative stress, inflammation, BNP and PAI-I levels inversely correlated with LV systolic, diastolic and atrial function.CONCLUSIONS:In patients with HT and normal EF, the most common HFPEF precursor condition, oxidative stress and inflammation may be responsible for LV systolic, diastolic and atrial dysfunction, which are important determinants of the transition of HT to HFPEF.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban heart failure hypertension Inflammation oxidative stress
Megjelenés:	Journal of Geriatric Cardiology 12 (2015), p. 1-10. -
További szerzők:	Fazakas Ádám Szénási Gábor Kiss Melinda Tegze, Narcis Fekete Bertalan C. Nagy Eszter (Budapest) Bodó Imre Nagy Bálint (1956-) (molekuláris genetikus) Molvarec Attila (szülész-nőgyógyász) Patócs Attila Pepó Lilla Prohászka Zoltán Vereckei András
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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