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001-es BibID:	BIBFORM065305
Első szerző:	Rosta Klára
Cím:	Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction / Klára Rosta, Attila Molvarec, Anna Enzsöly, Bálint Nagy, Zsolt Rónai, Andrea Fekete, Mária Sasvári-Székely, János Rigó Jr., Ágota Vér
Dátum:	2009
ISSN:	0301-2115
Megjegyzések:	Placental and systemic oxidative stress with an imbalance in the oxidant/antioxidant activity seems to play a central role in the pathogenesis of pre-eclampsia. The aim of our study was to examine whether two missense polymorphisms of the extracellular superoxide dismutase (SOD3) gene (Arg213Gly and Ala40Thr) are associated with pre-eclampsia in a Caucasian population from Hungary.Study designOne hundred and fifty-nine pre-eclamptic patients and 114 normotensive, healthy pregnant women were involved in this case-control study. The SOD3 Arg213Gly and Ala40Thr genotypes were determined using the polymerase chain reaction-restriction length polymorphism (PCR-RFLP) and allele-specific amplification methods.ResultsThe Arg213Gly variant was not detected in our population. There were no significant differences in the genotype and allele frequencies of the SOD3 Ala40Thr polymorphism between pre-eclamptic patients and control subjects. However, the mutant allele carriers of this polymorphism showed an increased risk for severe fetal growth restriction-complicated pre-eclampsia, which was independent of maternal age, prepregnancy BMI, primiparity and smoking status (OR: 6.07, 95% CI: 1.33?27.8, p = 0.020; adjusted OR: 4.89, 95% CI: 1.03?23.2, p = 0.046).ConclusionOur results suggest a role of SOD3 Ala40Thr single nucleotide polymorphism in the risk of severe fetal growth restriction-complicated pre-eclampsia. However, further studies are needed with a larger sample size to confirm our findings and to explore the exact molecular basis of this observation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban superoxide dismutase Ala40Ther gene polymorphism
Megjelenés:	European Journal Of Obstetrics Gynecology And Reproductive Biology. - 142 : 2 (2009), p. 134-138. -
További szerzők:	Molvarec Attila (szülész-nőgyógyász) Enzsöly Anna Nagy Bálint (1956-) (molekuláris genetikus) Rónai Zsolt Fekete Andrea Sasvári-Székely Mária Rigó János (1958-) (szülész-nőgyógyász) Vér Ágota
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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