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001-es BibID:	BIBFORM065310
Első szerző:	Than Nándor Gábor (szülész-nőgyógyász)
Cím:	Placental Protein 13 (galectin-13) has decreased placental expression but increased shedding and maternal serum concentrations in patients presenting with preterm preeclampsia and HELLP syndrome / Nandor Gabor Than, Omar Abdul-Rahman, Rita Magenheim, Balint Nagy, Tibor Fule, Beata Hargitai, Marei Sammar, Petronella Hupuczi, Adi L. Tarca, Gabor Szabo, Ilona Kovalszky, Hamutal Meiri, Istvan Sziller, Janos Rigo Jr., Roberto Romero, Zoltan Papp
Dátum:	2008
ISSN:	0945-6317
Megjegyzések:	Placental Protein 13 (PP13) is a galectin expressed by the syncytiotrophoblast. Women whosubsequently develop preterm preeclampsia have low first trimester maternal serum PP13concentrations. This study revealed that third trimester maternal serum PP13 concentration increasedwith gestational age in normal pregnancies (p<0.0001), and it was significantly higher in womenpresenting with preterm preeclampsia (p=0.02) and HELLP syndrome (p=0.01) than in pretermcontrols. Conversely, placental PP13 mRNA (p=0.03) and protein, as well as cytoplasmic PP13staining of the syncytiotrophoblast (p<0.05) was decreased in these pathological pregnanciescompared to controls. No differences in placental expression and serum concentrations of PP13 werefound at term between patients with preeclampsia and control women. In contrast, theimmunoreactivity of the syncytiotrophoblast microvillous membrane was stronger in both term andpreterm preeclampsia and HELLP syndrome than in controls. Moreover, large syncytial cytoplasmprotrusions, membrane blebs and shed microparticles strongly stained for PP13 in preeclampsia andHELLP syndrome. In conclusion, parallel to its decreased placental expression, an augmentedmembrane shedding of PP13 contributes to the increased third trimester maternal serum PP13concentrations in women with preterm preeclampsia and HELLP syndrome
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban placental protein 13 galectin-13 expression
Megjelenés:	Virchows Archiv. - 453 : 4 (2008), p. 387-400. -
További szerzők:	Abdul-Rahman, Omar Magenheim Rita Nagy Bálint (1956-) (molekuláris genetikus) Füle Tibor Hargitai Beáta Sammar, Marei Hupuczi Petronella (anaesthesiológus) Tarca, Adi Laurentiu Szabó Gábor (budapesti orvos) Kovalszky Ilona Meiri, Hamutal Sziller István (szülész-nőgyógyász szakorvos) Rigó János (1958-) (szülész-nőgyógyász) Romero, Roberto Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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