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001-es BibID:	BIBFORM065324
Első szerző:	Lázár Levente (szülész-nőgyógyász)
Cím:	Presence of Cell-Free Fetal DNA in Plasma of Women with Ectopic Pregnancies / Levente Lázár, Bálint Nagy, Zoltán Bán, Gyula R. Nagy, Zoltán Papp
Dátum:	2006
ISSN:	0009-9147
Megjegyzések:	BACKGROUND: The quantity of cell-free fetal DNA in the plasma of pregnant women changes during pregnancy and seems to be different in normal and pathologic pregnancies. We investigated the possible diagnostic applications of the detection and measurement of cell-free fetal DNA by comparing quantities found in women with ectopic (EP) or intrauterine (IUP) pregnancies. METHODS: We collected blood samples from 58 women who had positive pregnancy tests and specific complaints and sonographic findings suggestive of EP and from 45 women with confirmed IUP. We performed quantitative real-time PCR analysis of the sex-determining region Y (SRY) gene to detect and measure the amount of cell-free fetal DNA. The diagnosis of EP was confirmed by histologic examination. RESULTS: SRY was detected in 15 EP and 14 IUP cases. The mean (SD) amount of cell-free fetal DNA was significantly higher (P<0.005) in women with EP [565 (136) genome-equivalents (GE)/mL] than in women with IUP [72 (19) GE/mL] at the same gestational age. CONCLUSIONS: Our results confirm that cell-free fetal DNA is present in plasma of women with EP. The finding of higher amounts of cell-free fetal DNA in EP cases than in IUP cases suggests that this method might be useful for early diagnosis of EP.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban cell free fetal DNA plasma ectopic pregnancy
Megjelenés:	Clinical Chemistry. - 52 : 8 (2006), p. 1599-1601. -
További szerzők:	Nagy Bálint (1956-) (molekuláris genetikus) Bán Zoltán (nőgyógyász) Nagy Gyula Richárd (szülész-nőgyógyász) Papp Zoltán (1942-) (szülész-nőgyógyász, genetikus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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