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001-es BibID:	BIBFORM065326
Első szerző:	Koistinen, Hannu
Cím:	Glycodelin reduces carcinoma-associated gene expression in endometrial adenocarcinoma cells / Hannu Koistinen, Markku Seppälä, Balint Nagy, Johanna Tapper, Sakari Knuutila, Riitta Koistinen
Dátum:	2005
ISSN:	0002-9378
Megjegyzések:	OBJECTIVE:Glycodelin is a major secretory glycoprotein of differentiated endometrial epithelium, rarely expressed in proliferative endometrium or endometrial cancer. We aimed to elucidate its role in growth and gene expression of endometrial adenocarcinoma cells, and hypothesized that glycodelin affects cell growth and tumor-associated gene expression.STUDY DESIGN:Endometrial adenocarcinoma HEC-1B cells were transfected with glycodelin cDNA in both antisense and sense orientations. Cellular morphology, cell proliferation, and gene expression were compared between native and transfected cells.RESULTS:Compared with native and antisense-transfected carcinoma cells, sense-transfected, glycodelin-producing carcinoma cells showed reduced proliferation, morphologic changes, and altered expression of cancer-related genes. Notably, anti-apoptotic Bcl-XL and MUC1 genes were down-regulated.CONCLUSION:Reduction by glycodelin transfection of carcinoma cell proliferation and expression of MUC1 and Bcl-XL is significant because these genes are often overexpressed in human cancers--MUC1 is linked to invasive growth and metastases, and both confer resistance to chemotherapy. These results suggest a novel mechanism whereby malignant growth of endometrial adenocarcinoma cells is regulated.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban glycodelin carcinoma associated gene expression endometrial adenocarcinoma
Megjelenés:	American Journal Of Obstetrics And Gynecology. - 193 : 6 (2005), p. 1955-1960. -
További szerzők:	Seppälä, Markku Nagy Bálint (1956-) (molekuláris genetikus) Tapper, Johanna Knuutila, Sakari Koistinen, Riitta
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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