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001-es BibID:	BIBFORM065331
Első szerző:	Ferrer, Anna
Cím:	Different gene expression in immunoglobulin-mutated and immunoglobulin-unmutated forms of chronic lymphocytic leukemia / Anna Ferrer, Juha Ollila, Gerard Tobin, Bálint Nagy, Ulf Thunberg, Yan Aalto, Mauno Vihinen, Juhani Vilpo, Richard Rosenquist, Sakari Knuutila
Dátum:	2004
ISSN:	0165-4608
Megjegyzések:	The mutation status of the immunoglobulin heavy chain variable regions (IgVH) has been found to be a good prognostic indicator for B-cell chronic lymphocytic leukemia (CLL) because unmutated VH genes are associated with rapid disease progression and shorter survival time. To study the differences in gene expression between the Ig-unmutated and Ig-mutated CLL subtypes, we performed gene expression profiling on 31 CLL cases and investigated the VH gene mutation status by sequencing. The array data showed that the greatest variances between the unmutated (20 cases) and the mutated (11 cases) group were in expressions of ZAP70, RAF1, PAX5, TCF1, CD44, SF1, S100A12, NUP214, DAF, GLVR1, MKK6, AF4, CX3CR1, NAFTC1, and HEX. ZAP70 was significantly more expressed in the Ig-unmutated CLL group, whereas the expression of all the other genes was higher in the Ig-mutated cases. These results corroborate a recent finding, according to which the expression of ZAP70 can predict the VH mutation status and suggest that RAF1, PAX5, and other differentially expressed genes may offer good markers for differentiating unmutated cases from mutated cases and thus serve as prognostic markers.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban gene expression immunoglobulin mutated unmutated CLL
Megjelenés:	Cancer Genetics And Cytogenetics. - 153 : 1 (2004), p. 69-72. -
További szerzők:	Ollila, Juha Tobin, Gerard Nagy Bálint (1956-) (molekuláris genetikus) Thunberg, Ulf Aalto, Yan Vihinen, Mauno Vilpo, Juhani Rosenquist, Richard Knuutila, Sakari
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