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001-es BibID:	BIBFORM065355
Első szerző:	Szalai Csaba
Cím:	Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp(a) and MCP-1 : 2518 G/G genotype in CAD patients / Csaba Szalai, Jenő Duba, Zoltán Prohászka, Ákos Kalina, Teréz Szabó, Bálint Nagy, Laura Horváth, Albert Császár
Dátum:	2001
ISSN:	0021-9150
Megjegyzések:	The central role of chemokines in the pathogenesis of atherosclerosis has been made clear. Recently polymorphisms in the gene regulatory region of MCP-1 and in the promoter region of RANTES have been found, which increase the expression of these chemokines. We investigated the role of these polymorphisms together with the chemokine SDF-1?801A and the chemokine receptors CCR2-64I and CCR5?32 mutations in 318 patients with coronary artery disease (CAD) referred to coronary bypass surgery, comparing them with 320 healthy controls. The prevalence of the MCP-1 ?2518 G/G homozygotes was significantly higher among CAD patients than among controls (P<0.005; OR=2.2 (95% CI 1.25?3.92). The Lp(a) levels of CAD patients with G/G genotype were significantly higher than those in patients with G/A or A/A genotypes. No CAD patients homozygous for the CCR5?32 and CCR2-64I mutations have been found. The genotype distributions of the two alleles deviated from the Hardy Weinberg equilibrium in patients, indicating that the numbers of homozygotes were significantly lower than expected. The MCP-1 ?2518G variant in homozygous form appears as a genetic risk factor for severe CAD. This genotype is associated with elevated Lp(a) levels in patients. Individuals homozygous for CCR2-64I or CCR5?32 mutations are at reduced risk for severe CAD.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban polymorphism coronary artery Lp(a) Genotype
Megjelenés:	Atherosclerosis. - 158 : 1 (2001), p. 233-239. -
További szerzők:	Duba Jenő Prohászka Zoltán Kalina Ákos Szabó Terézia Nagy Bálint (1956-) (molekuláris genetikus) Horváth Laura Császár Albert
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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