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001-es BibID:	BIBFORM065356
Első szerző:	Kalina Ákos
Cím:	The association of serum lipoprotein(a) levels, apolipoprotein(a) size and (TTTTA)n polymorphism with coronary heart disease / Akos Kalina, Albert Csaszar, George Fust, Balint Nagy, Csaba Szalai, Istvan Karadi, Jeno Duba, Zoltan Prohaszka, Laura Horvath, Hans Dieplinger
Dátum:	2001
ISSN:	0009-8981
Megjegyzések:	Background: The association between lipoprotein(a) levels, apolipoprotein(a) size and the (TTTTA)n polymorphism which is located in the 5· non-coding region of the apo(a) gene was studied in 263 patients with severe coronary heart disease and 97 healthy subjects. Methods: Lp(a) levels were measured by ELISA, apo(a) isoform size was determined by SDS?agarose gel electrophoresis, and analysis of the (TTTTA)n was carried out by PCR. For statistical calculation, both groups were divided into low (at least one apo(a) isoform with ?22 Kringle IV) and high (both isoforms with >22 KIV) apo(a) isoform sizes, and into low number (<10 in both alleles) and high number of (?10 at least one allele) TTTTA repeats. Results: Lp(a) levels were higher (P=0.007), apo(a) isoforms size ?22 KIV and TTTTA repeats ?10 were more frequent (P=0.007 and 0.01) in cases than in controls. Lp(a) levels were found to be increased with low apo(a) weight in both groups (both P<0.0001). In multivariate logistic regression analysis, only the Lp(a) levels (P=0.005) and (TTTTA)n polymorphism (P=0.002) were found to be significantly associated with CHD. Conclusion: Nevertheless, these results indicate that in CHD patients the (TTTTA)n polymorphism has an effect on Lp(a) levels which is independent of the apo(a) size.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban apolipoprotein(a) (TTTTA)n Polymorphism serum association coronary heart diseases
Megjelenés:	Clinica Chimica Acta. - 309 : 1 (2001), p. 45-51. -
További szerzők:	Császár Albert Füst György (Budapest) Nagy Bálint (1956-) (molekuláris genetikus) Szalai Csaba Karádi István (1952-) (belgyógyász, kardiológus) Duba Jenő Prohászka Zoltán Horváth Laura Dieplinger, Hans
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