Találati lista | Tudóstér

001-es BibID:	BIBFORM065392
Első szerző:	Nagy Bálint (molekuláris genetikus)
Cím:	Leptin gene (TTTC)n microsatellite polymorphism in pre-eclampsia and HELLP syndrome / Nagy Balint, Varkonyi Tibor, Molvarec Attila, Lazar Levente, Hupuczi Petronella, Than Nandor Gabor, Rigo Janos Jr.
Dátum:	2009
ISSN:	1434-6621
Megjegyzések:	BACKGROUND:Leptin plays an important role in energy homeostasis. There is polymorphism on the leptin (LEP) gene. Our aim was to compare the tetranucleotide repeat (TTTC)(n) polymorphism in the 3'-flanking region in the LEP gene on DNA samples from patients with pre-eclampsia (PE), hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome and healthy pregnant controls.METHODS:Blood samples were collected from healthy pregnant women (n=88), patients with PE (n=79) and HELLP (n=77) syndrome. Fluorescent PCR and DNA fragment analysis was performed from the isolated DNA for the detection of (TTTC) repeats. The electrophoretograms were evaluated and patients were assigned to two groups; class I low (<190 bp) or class II high (> or =190 bp) PCR fragments.RESULTS:We observed similar distributions of the class I and class II (TTTC) alleles in the groups studied (class I allele: healthy pregnant 58.5%; severe pre-eclamptic 58.3%; HELLP syndrome 52.6%). We detected a higher frequency of the II/II genotype in HELLP syndrome patients (32.4%) compared to healthy controls (22.7%). However, the difference was not statistically significant.CONCLUSIONS:In an ethnically homogenous population, the LEP gene (TTTC) microsatellite polymorphism in the 3'-flanking region does not show a significant difference in the allele and genotype distribution in healthy pregnant, pre-eclamptic and HELLP syndrome patients. Furthermore, we recommend a new classification of the class I and class II alleles based on the distribution of the (TTTC) microsatellites.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban leptin gene microsatellite polymorphism
Megjelenés:	Clinical Chemistry And Laboratory Medicine 47 : 9 (2009), p. 1033-1037. -
További szerzők:	Várkonyi Tibor Molvarec Attila (szülész-nőgyógyász) Lázár Levente (szülész-nőgyógyász) Hupuczi Petronella (anaesthesiológus) Than Nándor Gábor (szülész-nőgyógyász) Rigó János (1958-) (szülész-nőgyógyász)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: