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001-es BibID:	BIBFORM066227
035-os BibID:	(WoS)000384016500018 (PM)27568546 (Scopus)84990851590
Első szerző:	Roqueta-Rivera, Manuel
Cím:	SETDB2 Links Glucocorticoid to Lipid Metabolism through Insig2a Regulation / Manuel Roqueta-Rivera, Ryan M. Esquejo, Peter E. Phelan, Katalin Sandor, Bence Daniel, Fabienne Foufelle, Jun Ding, Xiaoman Li, Sepideh Khorasanizadeh, Timothy F. Osborne
Dátum:	2016
ISSN:	1550-4131
Megjegyzések:	Transcriptional and chromatin regulations mediate the liver response to nutrient availability. The role of chromatin factors involved in hormonal regulation in response to fasting is not fully understood. We have identified SETDB2, a glucocorticoid-induced putative epigenetic modifier, as a positive regulator of GR-mediated gene activation in liver. Insig2a increases during fasting to limit lipid synthesis, but the mechanism of induction is unknown. We show Insig2a induction is GR-SETDB2 dependent. SETDB2 facilitates GR chromatin enrichment and is key to glucocorticoid-dependent enhancer-promoter interactions. INSIG2 is a negative regulator of SREBP, and acute glucocorticoid treatment decreased active SREBP during refeeding or in livers of Ob/Ob mice, both systems of elevated SREBP-1c-driven lipogenesis. Knockdown of SETDB2 or INSIG2 reversed the inhibition of SREBP processing. Overall, these studies identify a GR-SETDB2 regulatory axis of hepatic transcriptional reprogramming and identify SETDB2 as a potential target for metabolic disorders with aberrant glucocorticoid actions.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban SETDB2 SREBP fasting liver glucocorticoid receptor insig2
Megjelenés:	Cell Metabolism 24 : 3 (2016), p. 474-484. -
További szerzők:	Esquejo, Ryan M. Phelan, Peter E. Sándor Katalin (1987-) (molekuláris biológus, biokémikus-genomikus) Dániel Bence (1987-) (molekuláris biológus) Foufelle, Fabienne Ding, Jun Li, Xiaoman Khorasanizadeh, Sepideh Osborne, Timothy F.
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