Találati lista | Tudóstér

001-es BibID:	BIBFORM066503
Első szerző:	Juhász Balázs (orvos, onkológus)
Cím:	Comparison of peripheral quantitative computed tomography forearm bone density versus DXA in rheumatoid arthritis patients and controls / B. Juhász, K. Gulyás, Á. Horváth, Z. Pethő, H. P. Bhattoa, A. Váncsa, É. Szekanecz, C. Horváth, J. Kocsis, Z. Horváth, K. Hodosi, S. Szántó, G. Szűcs, Z. Szekanecz
Dátum:	2017
ISSN:	0937-941X
Megjegyzések:	AbstractSummaryRheumatoid arthritis (RA) has been associated with osteoporosis. Quantitative computed tomography (QCT) is capable of assessing bone density and composition. We found lower bone density in RA compared to controls. Age and RA duration influenced bone density. QCT may be useful to assess bone metabolism in RA.IntroductionRA is associated with generalized and periarticular osteoporosis. In addition to DXA that determines areal bone mineral density (BMD), peripheral QCT also detects volumetric BMD. QCT differentiates between total, trabecular, and cortical BMD. Here, we compared DXA and QCT in RA patients and healthy controls.MethodsBMD of 57 female RA patients and 32 age-matched healthy female controls were assessed by DXA. QCT of the forearm ultradistal region was also performed. Densitometry data were correlated with age, disease duration, disease activity, serum CRP, and anti-CCP levels.ResultsTotal bone density (310.4 ? 79.7 versus 354.0 ? 54.1 mg/cm3; p = 0.007) and attenuation (0.37 ? 0.05 versus 0.40 ? 0.03 1/cm; p = 0.001), trabecular density (157.6 ? 57.0 versus 193.8 ? 48.7 mg/cm3; p = 0.005) and attenuation (0.28 ? 0.03 versus 0.32 ? 0.04 1/cm; p < 0.0001), and cortical density (434.3 ? 115.8 versus 492.5 ? 64.0 mg/cm3; p = 0.006) and attenuation (0.44 ? 0.07 versus 0.47 ? 0.04 1/cm; p = 0.004) were significantly lower in RA. Both lumbar and femoral neck BMD, as well as T-scores, were significantly lower in RA versus controls (p < 0.001 in all cases). In RA, total and cortical QCT attenuation and density were associated with age, the presence of RA, and their combination. In contrast, trabecular density and attenuation were only affected by the presence of the disease but not by age. Also in RA, total trabecular and cortical density as determined by QCT significantly correlated with lumbar and/or femoral neck BMD as measured by DXA. Finally, anti-CCP seropositivity was associated with lower trabecular density and attenuation.ConclusionsBoth DXA and QCT may be suitable to study bone metabolism in RA. Areal BMD determined by DXA may correlate with volumetric bone density measured by QCT. Moreover, trabecular osteoporosis may be associated by the underlying autoimmune-inflammatory disease, while cortical osteoporosis may rather be age-related.KeywordsBone densitometry
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Bone densitometry
Megjelenés:	Osteoporosis International. - 28 : 4 (2017), p. 1271-1277. -
További szerzők:	Gulyás Katalin (reumatológus) Horváth Ágnes (1985-) (reumatológus) Pethő Zsófia (1981-) (reumatológus, immunológus) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Váncsa Andrea (1972-) (orvos) Szekanecz Éva (1968-) (onkológus szakorvos) Horváth C. (Budapest) Kocsis Judit (1967-) (onkológus) Horváth Zsolt (1964-) (onkológus, belgyógyász, klinikai farmakológus) Hódosi Katalin Szántó Sándor (1968-) (belgyógyász, reumatológus) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: