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001-es BibID:	BIBFORM066532
Első szerző:	Hitre Erika
Cím:	Thymidylate synthase (TS) gene polymorphisms affect disease free- (DFS) and overall (OS) survival of colorectal cancer (CRC) patients treated with adjuvant 5-fluorouracil-folinic acid (FUFA) / E. Hitre, V. Adleff, B. Budai, E. Szabó, Z. Horvath, I. Lang, F. Czeglédi, Z. Orosz, A. Gazdag, J. Kralovanszky
Dátum:	2004
ISSN:	0732-183X 1527-7755
Megjegyzések:	hymidylate synthase (TS) gene polymorphisms affect disease free- (DFS) and overall (OS) survival of colorectal cancer (CRC) patients treated with adjuvant 5-fluorouracil-folinic acid (FUFA)E. Hitre, V. Adleff, B. Budai, E. Szabó, Z. Horvath, I. Lang, F. Czeglédi, Z. Orosz...Show More Abstract3581Background: TS, the target enzym of 5-FU has a 28 bp polymorphism in the promoter region containing commonly double of triple tandem repeats of a 28 bp sequence (2R or 3R), and a 6bp ins/del polymorphism on the 3'UTR. Our aim was to study the influence of these TS polymorphisms on tumor response to adjuvant FUFA therapy in CRC patients. Methods: : 89 CRC patients receiving adjuvant FUFA were involved in the study. FUFA was given as bolus (Mayo regimen) or continuous infusion (de Gramont protocoll). TS polymorphisms were determined by PCR PAGE and RFLP method. Results: DFS was significantly longer (p=0,036 logrank test) in patients with +6/+6,+6/-6 genotypes than in ?6/-6 genotype.OS was significantly longer (p=0,025) in 3/3 genotype than in 2/3and 2/2 genotype. In rectal cancer +/+ and +/- 3'UTR patients had longer OS than -/- patients (p=0,007).No significant correlation between gene polymorphisms, age, gender, and localization were found. Conclusions: Both TS polymorphisms studied do affect the clinical outcome of the disease in CRC patients treated with adjuvant FUFA chemotherapy. Supported by the NKFP1/48/2001 grant.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:	Journal Of Clinical Oncology 22 (2004), p. 265. -
További szerzők:	Adleff Vilmos Budai Barna Szabó Eszter (onkológus) Horváth Zsolt (1964-) (onkológus, belgyógyász, klinikai farmakológus) Láng István Czeglédi Ferenc Orosz Zsolt Gazdag A. Kralovánszky Judit
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