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001-es BibID:	BIBFORM066611
035-os BibID:	(Scopus)84984994050 (WoS)000382300300005
Első szerző:	Máthé Csaba (biológus)
Cím:	The Effects of microcystins (Cyanobacterial Heptapeptides) on the eukaryotic cytoskeletal system / Csaba Máthé, Dániel Beyer, Márta M-Hamvas, Gábor Vasas
Dátum:	2016
ISSN:	1389-5575 1875-5607
Megjegyzések:	Microcystins (MCYs) are cyanobacterial heptapeptides known for their high toxicity ineukaryotic cells and for their potential human health hazards. They are potent and specific inhibitorsof type 1 and 2A, serine-threonine protein phosphatases (PP1 and PP2A) and as such, interfere withkey cellular and metabolic events. Moreover, they induce oxidative stress involving reactive oxygenspecies (ROS) generation. Their cytoskeletal effects involve both mitotic and differentiated eukaryoticcells. The main objective of the present review is to summarize the most important cytoskeletal effectsof MCY on human, animal and plant cells known to date and to give an insight into the cellular and molecular backgroundof these alterations. Disruptions of microtubule (MTs), microfilament (MF) and intermediate filament (IF) organizationhave all been described, having consequences on cell shape, tissue integrity and functionality and mitotic division. Mostof these subcellular changes are closely related to PP1 and PP2A inhibition and involve misfunctioning of cytoskeletonassociated proteins. However, several cytoskeletal alterations are likely to be related to the induction of oxidative stress.MCY induced changes in MT, MF and IF assembly may have severe human health consequences. The main target ofcyanotoxin in human/ animal cells is liver and cytoskeletal disruption alters structure and functioning of hepatocytes.However, many other cell types undergo alterations similar to those observed in hepatocytes. Both PP1/PP2A inhibitionand ROS generation are involved and the activation of mitogen activated protein kinases (MAPKs) seems to play a crucialrole in the molecular events leading to cytoskeletal disruption.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Intermediate filaments microcystin microfilaments microtubules oxidative stress protein phosphatase
Megjelenés:	Mini-Reviews in Medicinal Chemistry. - 16 : 13 (2016), p. 1063-1077. -
További szerzők:	Beyer Dániel (1982-) (molekuláris biológus) Mikóné Hamvas Márta (1963-) (biológus) Vasas Gábor (1975-) (biológus-vegyész)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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