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001-es BibID:	BIBFORM066671
035-os BibID:	(WoS)000395934200028 (Scopus)85011586116
Első szerző:	Németh Norbert (kutatóorvos)
Cím:	Hemorheological factors can be informative in comparing treatment possibilities of abdominal compartment syndrome / Nemeth Norbert, Peto Katalin, Deak Adam, Sogor Viktoria, Varga Gabor, Tanczos Bence, Balog Klaudia, Csiszko Adrienn, Godo Zoltan, Szentkereszty Zsolt
Dátum:	2016
ISSN:	1386-0291
Megjegyzések:	BACKGROUND: Abdominal compartment syndrome (ACS) is a life-threatening condition, of which pathomechanism hasn't been completely clarified, yet. Furthermore, surgical therapy still needs optimization. OBJECTIVE: We aimed to investigate microcirculatory and micro-rheological alterations in ACS, using various temporary abdominal closure methods, including three settings of vacuum-assisted closure technique (negative pressure wound therapy, NPWT). METHODS: On anesthetized pigs, by intraabdominally placed and filled-up silicone bags, intraabdominal pressure at 30?mmHg was maintained for 3 hours, and afterwards, decompressive laparotomy happened. In different experimental groups Bogota-bag or Vivano-sets were applied (?50, ?100, ?150 mmHg) for 2 hours. Pressure monitoring was done by implanted sensors, hemorheological parameters were determined, and laser Doppler flowmetry tests were performed on the surface of intraabdominal organs. RESULTS: Treatment with Bogota-bag and ?150?mmHg vacuum increased erythrocyte aggregation, while deformability declined. Blood viscosity increased after treatment with ?150?mmHg vacuum. The microcirculatory parameters of the NPWT groups were better in case of the small intestine. CONCLUSIONS: ACS resulted in impairment of macro- and micro-rheological parameters and abdominal organs' microcirculation. All of the used techniques improved the results, however, applying Bogota-bag or ?150?mmHg vacuum set showed worse microcirculatory and micro-rheological data than the settings at ?100 or ?50 mmHg.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk abdominal compartment syndrome negative pressure wound therapy microcirculation hemorheology
Megjelenés:	Clinical Hemorheology And Microcirculation. - 64 : 4 (2016), p. 765-775. -
További szerzők:	Pető Katalin (1961-) (kutatóorvos) (Kísérletes orvostudomány) Deák Ádám (1974-) (állatorvos) Somogyi Viktória (1989-) (biotechnológus) Varga Gábor (1993-) (általános orvos) Tánczos Bence (1987-) (biológus) Balog Klaudia (1988-) (sebész szakorvos) Csiszkó Adrienn Godó Zoltán (1972-) (biológus, informatikus) Szentkereszty Zsolt (1961-) (sebész)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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