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001-es BibID:	BIBFORM067302
035-os BibID:	(WoS)000388546800022 (Scopus)84993990174
Első szerző:	Garda Zoltán (vegyész)
Cím:	Physico-chemical properties of MnII complexes formed with cis- and trans-DO2A : thermodynamic, electrochemical and kinetic studies / Zoltán Garda, Attila Forgács, Quyen N. Do, Ferenc K. Kálmán, Sarolta Timári, Zsolt Baranyai, Lorenzo Tei, Imre Tóth, Zoltán Kovács, Gyula Tircsó
Dátum:	2016
ISSN:	0162-0134 1873-3344
Megjegyzések:	Manganese (MnII) is a promising alternative to gadolinium (GdIII) as a magnetic resonance imaging (MRI) agent. Unlike gadolinium, this biogenic metal might be better tolerated by the body, reducing the risk of toxicity associated with dissociation of the complex. Herein we report detailed equilibrium and kinetic studies performed with MnII complexes of 1,4,7,10-tetraazacyclododecane-1,4-diacetic acid (1,4-DO2A or cis-DO2A) and 1,4,7,10-tetraazacyclododecane-1,7-diacetic acid (1,7-DO2A or trans-DO2A). The protonation constants of the ligands as well as stability constants of their MnII complexes have been determined by pH-potentiometry. The stability constants of [Mn(cis-DO2A)] are slightly higher than those of [Mn(trans-DO2A)] (log KMnL = 15.68 and 15.22, respectively). Cyclic voltammetric (CV) experiments performed on [Mn(cis-DO2A)] and [Mn(trans-DO2A)] revealed quasireversible systems with a half-wave potential of + 636 and + 705 mV versus Ag/AgCl, respectively. These values indicate that the MnII ion in these complexes is more stabilized against the oxidation than in [Mn(EDTA)]2 ?. The kinetic inertness of the complexes has been studied in transmetallation reactions with CuII or ZnII ions. Kinetic measurements indicate that both MnII complexes primarily undergo acid catalyzed dissociation and positions of the acetate pendant arms do not influence kinetic inertness. The inertness of these complexes is comparable to that of [Mn(NOTA)]? (NOTA = 1,4,7-triazacyclononane-1,4,7-triacetic acid) and about twenty times lower than that of [Mn(DOTA)]2 ? (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid). In conclusion, [Mn(cis-DO2A)] displays some very interesting features (thermodynamic and redox stability as well as kinetic inertness) which makes this complex a promising platform for the development of more efficient MnII complexes as alternatives to Gd-based MRI agents.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Magnetic resonance imaging Contrast agents (CAs) Manganese Thermodynamic stability Inertness Electrochemistry
Megjelenés:	Journal of Inorganic Biochemistry. - 163 (2016), p. 206-213. -
További szerzők:	Forgács Attila (1988-) (vegyész) Do, Quyen N. (1975-) (vegyész) Kálmán Ferenc K. (1978-) (vegyész) Timári Sarolta (1984-) (vegyész, kémia tanár) Baranyai Zsolt (1977-) (vegyész) Tei, Lorenzo Tóth Imre (1950-) (vegyész) Kovács Zoltán (1963-) (vegyész, angol szakfordító) Tircsó Gyula (1977-) (vegyész, kémia tanár)
Pályázati támogatás:	OTKA-84291 OTKA OTKA-109029 OTKA TÁMOP 4.2.4. A/2-11-1-2012-0001 TÁMOP COST TD1004 Action "Theragnostics Imaging and Therapy: An Action to Develop Novel Nanosized Systems for Imaging-Guided Drug Delivery" Egyéb Bólyai János Kutatási Ösztöndíj MTA
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