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001-es BibID:	BIBFORM067757
Első szerző:	Paciaroni, Maurizio
Cím:	Prediction of Early Recurrent Thromboembolic Event and Major Bleeding in Patients With Acute Stroke and Atrial Fibrillation by a Risk Stratification Schema / Maurizio Paciaroni, Giancarlo Agnelli, Valeria Caso, Georgios Tsivgoulis, Karen L. Furie, Prasanna Tadi, Cecilia Becattini, Nicola Falocci, Marialuisa Zedde, Azmil H. Abdul-Rahim, Kennedy R. Lees, Andrea Alberti, Michele Venti, Monica Acciarresi, Cataldo D'Amore, Maria Giulia Mosconi, Ludovica Anna Cimini, Antonio Procopio, Paolo Bovi, Monica Carletti, Alberto Rigatelli, Manuel Cappellari, Jukka Putaala, Liisa Tomppo, Turgut Tatlisumak, Fabio Bandini, Simona Marcheselli, Alessandro Pezzini, Loris Poli, Alessandro Padovani, Luca Masotti, Vieri Vannucchi, Sung-Il Sohn, Gianni Lorenzini, Rossana Tassi, Francesca Guideri, Maurizio Acampa, Giuseppe Martini, George Ntaios, Efstathia Karagkiozi, George Athanasakis, Kostantinos Makaritsis, Kostantinos Vadikolias, Chrysoula Liantinioti, Maria Chondrogianni, Nicola Mumoli, Domenico Consoli, Franco Galati, Simona Sacco, Antonio Carolei, Cindy Tiseo, Francesco Corea, Walter Ageno, Marta Bellesini, Giovanna Colombo, Giorgio Silvestrelli, Alfonso Ciccone, Umberto Scoditti, Licia Denti, Michelangelo Mancuso, Miriam Maccarrone, Giovanni Orlandi, Nicola Giannini, Gino Gialdini, Tiziana Tassinari, Maria Luisa De Lodovici, Giorgio Bono, Christina Rueckert, Antonio Baldi, Sebastiano D'Anna, Danilo Toni, Federica Letteri, Martina Giuntini, Enrico Maria Lotti, Yuriy Flomin, Alessio Pieroni, Odysseas Kargiotis, Theodore Karapanayiotides, Serena Monaco, Mario Maimone Baronello, Laszló Csiba, Lilla Szabó, Alberto Chiti, Elisa Giorli, Massimo Del Sette, Davide Imberti, Dorjan Zabzuni, Boris Doronin, Vera Volodina, Patrik Michel, Peter Vanacker, Kristian Barlinn, Lars-Peder Pallesen, Jessica Kepplinger, Ulf Bodechtel, Johannes Gerber, Dirk Deleu, Gayane Melikyan, Faisal Ibrahim, Naveed Akhtar, Vanessa Gourbali, Shadi Yaghi
Dátum:	2017
ISSN:	0039-2499
Megjegyzések:	Background and PurposesThis study was designed to derive and validate a score to predict early ischemic events and major bleedings after an acute ischemic stroke in patients with atrial fibrillation.MethodsThe derivation cohort consisted of 854 patients with acute ischemic stroke and atrial fibrillation included in prospective series between January 2012 and March 2014. Older age (hazard ratio 1.06 for each additional year; 95% confidence interval, 1.00?1.11) and severe atrial enlargement (hazard ratio, 2.05; 95% confidence interval, 1.08?2.87) were predictors for ischemic outcome events (stroke, transient ischemic attack, and systemic embolism) at 90 days from acute stroke. Small lesions (?1.5 cm) were inversely correlated with both major bleeding (hazard ratio, 0.39; P=0.03) and ischemic outcome events (hazard ratio, 0.55; 95% confidence interval, 0.30?1.00). We assigned to age ?80 years 2 points and between 70 and 79 years 1 point; ischemic index lesion >1.5 cm, 1 point; severe atrial enlargement, 1 point (ALESSA score). A logistic regression with the receiver-operating characteristic graph procedure (C statistic) showed an area under the curve of 0.697 (0.632?0.763; P=0.0001) for ischemic outcome events and 0.585 (0.493?0.678; P=0.10) for major bleedings.ResultsThe validation cohort consisted of 994 patients included in prospective series between April 2014 and June 2016. Logistic regression with the receiver-operating characteristic graph procedure showed an area under the curve of 0.646 (0.529?0.763; P=0.009) for ischemic outcome events and 0.407 (0.275?0.540; P=0.14) for hemorrhagic outcome events.ConclusionsIn acute stroke patients with atrial fibrillation, high ALESSA scores were associated with a high risk of ischemic events but not of major bleedings.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban atrial fibrillation myocardial infarction risk stratification stroke
Megjelenés:	Stroke 48 : 3 (2017), p. 726-732. -
További szerzők:	Agnelli, Giancarlo Caso, Valeria Tsivgoulis, Georgios Furie, Karen L. Tadi, Prasanna Becattini, Cecilia Falocci, Nicola Zedde, Marialuisa Abdul-Rahim, Azmil H. Lees, Kennedy R. Alberti, Andrea Venti, Michele Acciarresi, Monica D'Amore, Cataldo Mosconi, Maria Giulia Cimini, Ludovica Anna Procopio, Antonio Bovi, Paolo Carletti, Monica Rigatelli, Alberto Cappellari, Manuel Putaala, Jukka Tomppo, Liisa Tatlisumak, Turgut Bandini, Fabio Marcheselli, Simona Pezzini, Alessandro Poli, Loris Padovani, Alessandro Masotti, Luca Vannucchi, Vieri Sohn, Sung-Il Lorenzini, Gianni Tassi, Rossana Guideri, Francesca Acampa, Maurizio Martini, Giuseppe Ntaios, George Karagkiozi, Efstathia Athanasakis, George Makaritsis, Kostantinos Vadikolias, Kostantinos Liantinioti, Chrissoula Chondrogianni, Maria Mumoli, Nicola Consoli, Domenico Galati, Franco Sacco, Simona Carolei, Antonio Tiseo, Cindy Corea, Francesco Ageno, Walter Bellesini, Marta Colombo, Giovanna Silvestrelli, Giorgio Ciccone, Alfonso Scoditti, Umberto Denti, Licia Mancuso, Michelangelo Maccarrone, Miriam Orlandi, Giovanni Giannini, Nicola Gialdini, Gino Tassinari, Tiziana De Lodovici, Maria Luisa Bono, Giorgio Rueckert, Christina Baldi, Antonio D'Anna, Sebastiano Toni, Danilo Letteri, Federica Giuntini, Martina Lotti, Enrico Maria Flomin, Yuriy Pieroni, Alessio Kargiotis, Odysseas Karapanayiotides, Theodore Monaco, Serena Baronello, Mario Maimone Csiba László (1952-) (neurológus, pszichiáter) Szabó Lilla (1976-) (egyetemi tanár) Chiti, Alberto Giorli, Elisa Del Sette, Massimo Imberti, Davide Zabzuni, Dorjan Doronin, Boris Volodina, Vera Michel, Patrik Vanacker, Peter Barlinn, Kristian Pallesen, Lars-Peder Kepplinger, Jessica Bodechtel, Ulf Gerber, Johannes Deleu, Dirk Melikyan, Gayane Ibrahim, Faisal Akhtar, Naveed Gourbali, Vanessa Yaghi, Shadi
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