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001-es BibID:	BIBFORM067886
Első szerző:	Bácskai Tímea (biológus, neurobiológus)
Cím:	Effect of chronic fluorokinolone treatment on the structures innervating the salivary glands of the rat / Bácskai Tímea, Kelentey Barna, Deák Ádám, Zelles Tivadar, Skopkó Boglárka, Matesz Klára
Dátum:	2007
ISSN:	1065-6766
Megjegyzések:	Fluorokinolones (i.e. Peflacine, PEF) are used in the dental and medical therapy. It was demonstrated that chronic treatment on the rats resulted in disturbance in the secretory function of the salivary glands accompanied by the morphological sign of atrophy in the secretory units. The mechanism of this impairment is unknown. Because the peripheral neuropathy was previously described as the toxic side effect of the chronic PEF treatment we proposed that the morphological and funcional disorder of salivary glands developed on the basis of a neuronal disorder. Earlier studies described, that the mast cells could release nerve growth factor (NGF), which is important in the surviving of neurons. The lack of NGF results degenerative processes in the peripheral neurons which can change the expression of neuropeptides (i.e. serotonin, SER).The aim of this study was to determine the number of mast cells and the qualitative and quantitative changes of SER immunoreactive (IR) nerve terminals in the salivary glands after PEF treatment. Adult rats were treated with PEF for 3 and 7 days. For the visualization of mast cells we have used Toluidine blue staining. Immunohisthochemical methods were used to detect the SER containing fibers on the salivary glands. After the chronic treatment we could detect the incresed number of mast cells which supports the protective role of the NGF. The number of SER IR fibers decreased compared to the control. The changes in the number of IR fibers support our previous results, that local denervation of Salivary gland can cause the atrophy of the acini.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idézhető absztrakt saliva
Megjelenés:	Clinical Neuroscience. - 2007. (2007), p. 7. -
További szerzők:	Kelentey Barna (1959-) (fogszakorvos) Deák Ádám (1974-) (állatorvos) Zelles Tivadar Skopkó Boglárka Emese (1986-) (fogszakorvos) Matesz Klára (1949-) (anatómus, neurobiológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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