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001-es BibID:	BIBFORM068398
Első szerző:	Orosz László (szülész-nőgyógyász)
Cím:	Maternal characteristics, ultrasound- and serum-markers at 11-13+6 weeks in pregnancies without pre-eclampsia resulting small for gestational age neonates / Orosz, L., Orosz, G., Arany, I., Fabian, A., Pap, K., Medve, L., Tóth, Z., Poka, R., Torok, O.
Dátum:	2014
ISSN:	0960-7692
Megjegyzések:	ObjectivesSmall for gestational age (SGA) newborns are generally defined as those with a birthweight below the 10th percentile for the specific gestational age. Our aim was to investigate whether the first trimester maternal biophysical, ultrasound and serum markers show any difference between SGA and appropriate for gestational age (AGA) fetuses in pregnancies not complicated with pre-eclampsia.MethodsThis is a retrospective analysis of the data from a prospective study (TÁMOP 4.2.4. A/2-11-1-2012-0001 ♭NationalExcellence Program') for adverse pregnancy outcomes by first-trimester screening. MoM levels of serum analytes (pregnancy-associated plasma protein A (PAPP-A), human chorionic gonadotrophin (B-hCG), mean arterial pressure (MAP), body mass index (BMI), parity, smoking status, maternal history and uterine artery Doppler pulsatility index (UAPI), obtained between 11 and 13?+?6 weeks gestation, were compared between the groups of pregnancies that ended up in the delivery of alive SGA or AGA newborns. Neonates born between 24-41 weeks were included, but pregnancies with pre-eclampsia or large for gestational age (LGA) fetuses were excluded.Results1112 women were recruited in the study population, out of which 720 were selected for the analysis. Overall 40 SGA fetuses were compared with 680 controls. There were significant differences between the maternal socioeconomic status, BMI, smoking status, while there were no significant differences between the maternal age and parity. Among the first trimester markers the PAPP-A level was significantly lower and the UAPI was significantly higher in the SGA group, while there was no significant difference in the B-hCG and MAP levels between the two groups.ConclusionsThere are significant differences in the first trimester markers when comparing the two groups of pregnancies resulting SGA and AGA neonates. Further prospective studies are required to develop a cost effective screening method for SGA neonates at the 11-13?+?6 weeks.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt SGA
Megjelenés:	Ultrasound In Obstetrics & Gynecology 44 : S1 (2014), p. 264. -
További szerzők:	Orosz Gergő Balázs (1985-) (szülész-nőgyógyász) Arany István Fábián Anna Pap Károly Medve László Tóth Zoltán (1948-) (szülész-nőgyógyász, humángenetikus) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Török Olga (1956-) (szülész-nőgyógyász, humángenetikus)
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