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001-es BibID:	BIBFORM068399
Első szerző:	Orosz László (szülész-nőgyógyász)
Cím:	The contribution of PLGF to the performance of screening for severe pre-eclampsia in the first trimester of pregnancy in routine clinical practice / Orosz, L., Orosz, G., Arany, I., Fabian, A., Pap, K., Medve, L., Tóth, Z., Poka, R., Torok, O.
Dátum:	2014
ISSN:	0960-7692
Megjegyzések:	ObjectivesThe association between pre-eclampsia (PE),first trimester high uterine artery pulsatility index (UtA-PI),low maternal serum pregnancy-associated plasma protein A (PAPP-A), placental growth factor (PLGF) levels and certain maternal characteristics is well known. Earlier studies have shown that these first trimester markers can predict PE with a detection rate of 60-90%. The aim of this study (TÁMOP4.2.4.A/2-11-1-2012-0001) was to determine the contribution of PLGF to the performance of screening for severe PE in singleton pregnancies in our routine clinical practice.MethodsThis is a pilot study of our prospective study for adverse pregnancy outcomes by first-trimester screening. In the study the patient-specific first trimester risks of PE was calculated by a combination of maternal factors (age, ethnic origin, method of conception, body mass index (BMI), parity, smoking status, previous history of PE,mean arterial blood pressure (MAP)), mean UtA-PI and PAPP-A. PLGF was measured retrospectively from stored serum samples, and the risk was recalculated in each patient. Screen positive patients were determined by Astraia 2.8 program.ResultsBetween 2010-2012, 1112 women were recruited in the prospective study. Out of these, 75 cases were selected:17 cases of severe PE and 58 random control patients. The overall detection rate of severe PE 58.8% (10/17) did not improve by adding PLGF to the risk calculation, but the false positive rate decreased from 10,4% (6/58) without PLGF to 6,8% (4/58) with PLGF.ConclusionsCombination of these factors allows calculation of risk for PE in the first trimester. The detection rate (58,8%) of severe PE in our study is comparable with the published data. The contribution of PLGF to the screening efficacy was shown by the decreased false positive ratio. This reduction is not significant, our hypothesis must be tested on a larger sample of population. Further biochemical markers as angiogenetic factors measured in the first trimester might improve the detection rate.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt Severe preeclampsia
Megjelenés:	Ultrasound In Obstetrics & Gynecology 44 : S1 (2014), p. 270-270. -
További szerzők:	Orosz Gergő Balázs (1985-) (szülész-nőgyógyász) Arany István Fábián Anna Pap Károly Medve László Tóth Zoltán (1948-) (szülész-nőgyógyász, humángenetikus) Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus) Török Olga (1956-) (szülész-nőgyógyász, humángenetikus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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