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001-es BibID:	BIBFORM068400
Első szerző:	Orosz László (szülész-nőgyógyász)
Cím:	Screening for pre-eclampsia during the first trimester in routine clinical practice : a prospective study / Orosz, L., Orosz, G., id. Orosz, L., Fabian, A., Tóth, Z., Török, O.
Dátum:	2012
ISSN:	0960-7692
Megjegyzések:	ObjectivesThe association between pre-eclamsia (PE) and first trimester high uterine artery pulsatility index (UtA-PI), low maternal serum pregnancy-associated plasma protein-A (PAPP-A) level and certain maternal factors is well known. Several retrospective studies have shown that these first trimester markers can predict PE with a detection rate of 60?90%. The aim of this prospective study was to determine the performance of screening for PE in singleton pregnancies during routine clinical practice.MethodsBetween 2011?2012 measurements of UtA-PI were performed at 11?13 + 6 weeks, and mean pulsatility index (PI) was calculated. Doppler, maternal history and biometry variables (age, ethnic origin, method of conception, BMI, parity, smoking, family or personal history of hypertension or PE, blood pressure) were combined with first trimester PAPP-A to assess the risk of PE. Astraia Software 2.3.2 was used in risk calculation.Results2552 women were recruited after informed consent to the study, and outcome data were available in 950 (37.2%) cases. PE occurred in 36 (3.8%) patients. The overall detection rate of early and late PE was 44.4% (16/36) with a false positive rate (FPR) of 12.3% (112/914). There were only 2 cases with early PE, the detection rate was 50% (1/2), with a FPR of 18.7% (178/948). The detection rate of the late PE (delivery at 34th weeks or after) was 44.1% (15/34), with a FPR of 9.5% (87/914).ConclusionsCombining risk factors in the mother's history with UtA-PI allows calculation of patient-specific risk for the development of PE. Because of the small number of early PE cases in our study population our detection rate can not be taken into consideration. The detection rate (44%) of late PE in our study is comparable with the published retrospective data (60%). The Astraia software used only serum PAPP-A for risk calculation. Further biochemical markers might improve the detection rate. Follow-up of our recruited cases is still going on.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt Screening for preeclampsia
Megjelenés:	Ultrasound In Obstetrics & Gynecology. - 40 : S1 (2012), p. 199-200. -
További szerzők:	Orosz Gergő Balázs (1985-) (szülész-nőgyógyász) id. Orosz László Fábián Anna Tóth Zoltán (1948-) (szülész-nőgyógyász, humángenetikus) Török Olga (1956-) (szülész-nőgyógyász, humángenetikus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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