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001-es BibID:	BIBFORM068952
Első szerző:	DeVelasco, E. Alonso
Cím:	Adjuvant Quil A improves protection in mice and enhances opsonic capacity of antisera induced by pneumococcal polysaccharide conjugate vaccines / DeVelasco E. Alonso, Dekker H. A. Th., Antal-Szalmás Péter, Jalink K. P., van Strijp Jos A. G., Verheul André F. M., Verhoef Jan, Snippe H.
Dátum:	1994
ISSN:	0264-410X
Megjegyzések:	The adjuvant Quil A has been found to enhance theresponse of mice to pneumococcal polysaccharides,polysaccharide-protein conjugates and oligosaccharideproteinconjugates I 3. Quil A augments the antipolysaccharideimmunoglobulin M (IgM) and IgG titre,changes the IgG sub-isotype distribution, and increasesthe avidity of the antibodies specific for the nativepolysaccharide after immunization with synthetic oligosaccharideconjugates. Although Quil A has a minimaleffect on the magnitude of the antibody responseof rabbits to meningococcal oligosaccharide proteinconjugates, it influences the epitope specificity of theantibodies induced 4'5. In a previous study 1, no effect ofQuil A was observed on the secondary antibody responsein mice to pneumococcal polysaccharide 17F (PS)conjugated to keyhole limpet haemocyanin (KLH). Thiswas probably due to the strong immunogenicity of theconjugate itself. Therefore, in this paper we investigatedwhether Quil A would have an effect on the primaryantibody response to the same conjugate, and a similarlyprepared conjugate differing in PS/KLH ratio. Theprimary response in mice was assessed by (i) the levelsof PS-specific antibody induced, measured by anenzyme-linked immunosorbent assay (ELISA), (ii) theprotection against a lethal challenge with S. pneumoniae17F, and (iii) the in vitro opsonic activity of the antisera.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban monocytes internalization CD14
Megjelenés:	Vaccine 12 : 15 (1994), p. 1419-1422. -
További szerzők:	Dekker, H. A. Th. Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Jalink, K. P. Strijp, Jos A. G., van Verheul, André F. M. Verhoef, Jan Snippe, H.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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