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001-es BibID:	BIBFORM068983
Első szerző:	Nagy Gábor
Cím:	Measurement of intracellular interferon-gamma and interleukin-4 in whole blood T lymphocytes from patients with systemic lupus erythematosus / G. Nagy, É. Pállinger, P. Antal-Szalmás, M. Aleksza, M. Marschalkó, M. Brózik, A. Falus, P. Gergely
Dátum:	2000
ISSN:	0165-2478
Megjegyzések:	Contradictory data are available about the dominance of T-helper 1 (TH1), or T-helper 2 (TH2) cytokines in systemic lupuserythematosus (SLE). Therefore, intracellular interferon-gamma (IFN-g) and interleukin-4 (IL-4) production of T lymphocyteswas measured in whole blood of healthy donors and active and inactive SLE patients by flow cytometry. The percentage of IFN-gand IL-4 positive cells was low (B1%) in unstimulated samples of the healthy controls, while that of IFN-g and IL-4 positive cellsin the stimulated cells was 25.2910.6% and 0.691.5%, respectively. No significant difference was found between SLE patientsand healthy controls and between active and inactive patients in these parameters either in the unstimulatad or in the stimulatedsamples. One patient with severe disease had as high as 11.8% IL-4 positive cells and 12.5% IFN-g positive cells in the stimulatedsamples, but after the initiation of intensive corticosteroid and cytostatic therapy, the percentage of IL-4 positive T cells decreased(4.76%) while that of IFN-g positive T cells increased (47.91%). We conclude that the intracellular IL-4 and IFN-g expression ofT lymphocytes does not differ markedly between SLE patients and healthy controls, with the possible exception of severe disease,when marked IL-4 overproduction may exist beside low IFN-g production. Furthermore, corticosteroid and cytostatic therapymight normalize this altered IFN-g:IL-4 ratio. ? 2000 Elsevier Science B.V. All rights reserved.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Immunology Letters. - 74 (2000), p. 207-210. -
További szerzők:	Pállinger Éva Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Aleksza Magdolna Marschalkó Márta Brózik M. Falus András Gergely Péter (Budapest)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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