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001-es BibID:	BIBFORM069211
Első szerző:	Ragin, Camille
Cím:	Prevalence of HPV Infection in Racial-Ethnic Subgroups of Head and Neck Cancer Patients / Ragin Camille, Liu Jeffrey C., Jones Gieira, Shoyele Olubunmi, Sowunmi Bukola, Kennett Rachel, Groen Harry J. M., Gibbs Denise, Blackman Elizabeth, Esan Michael, Brandwein Margaret S., Devarajan Karthik, Bussu Francesco, Chernock Rebecca, Chien Chih-Yen, Cohen Marc A., Samir El-Mofty, Mikio Suzuki, D'Souza Gypsyamber, Funchain Pauline, Eng Charis, Gollin Susanne M., Hong Angela, Jung Yuh-S., Krüger Maximilian, Lewis James, Morbini Patrizia, Landolfo Santo, Rittà Massimo, Straetmans Jos, Szarka Krisztina, Tachezy Ruth, Worden Francis P., Nelson Deborah, Gathere Samuel, Taioli Emanuela
Dátum:	2017
ISSN:	0143-3334
Megjegyzések:	The landscape of HPV infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3,129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was higher among Blacks with oropharyngeal cancer than Blacks with non-oropharyngeal cancer. However, there was great heterogeneity observed among studies (Q test P<0.0001). In the pooled analysis, after adjusting for each study, year of diagnosis, age, gender and smoking status, the prevalence of HPV16/18 in oropharyngeal cancer patients was highest in Whites (61.1%), followed by 58.0% in Blacks and 25.2% in Asians (P<0.0001). There was no statistically significant difference in HPV16/18 prevalence in non-oropharyngeal cancer by race (P=0.682). With regard to the pattern of HPV16/18 status and p16 expression, White patients had the highest proportion of HPV16/18+/p16+ oropharyngeal cancer (52.3%), while Asians and Blacks had significantly lower proportions (23.0% and 22.6%, respectively) [P <0.0001]. Our findings suggest that the pattern of HPV16/18 status and p16 expression in oropharyngeal cancer appears to differ by race and this may contribute to survival disparities.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Carcinogenesis 38 : 2 (2017), p. 218-229. -
További szerzők:	Liu, Jeffrey C. Jones, Gieira Shoyele, Olubunmi Sowunmi, Bukola Kennett, Rachel Groen, Harry J. M. Gibbs, Denise Blackman, Elizabeth Esan, Michael Brandwein, Margaret S. Devarajan, Karthik Bussu, Francesco Chernock, Rebecca Chien, Chih-Yen Cohen, Marc A. Samir, El-Mofty Mikio, Suzuki D'Souza, Gypsyamber Funchain, Pauline Eng, Charis Gollin, Susanne M. Hong, Angela Jung, Yuh-S. Krüger, Maximilian Lewis, James Morbini, Patrizia Landolfo, Santo Rittà, Massimo Straetmans, Jos Szarka Krisztina (1971-) (molekuláris biológus, mikrobiológus) Tachezy, Ruth Worden, Francis P. Nelson, Deborah Gathere, Samuel Taioli, Emanuela
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