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001-es BibID:	BIBFORM069285
Első szerző:	Aiello, Francesca B.
Cím:	Inducible accessory function of a macrophage cell line / F. B. Aiello, L. Gusella, D. L. Longo, M. Birchenall-Roberts, L. Takacs, F. Takei, F. Ruscetti, P. Musiani, S. K. Durum
Dátum:	2008
ISSN:	0892-3973
Megjegyzések:	Costimulatory molecules in addition to occupancy of the T-cell antigenreceptor, are required to induce T-cell proliferation.Previous worksuggested that membrane molecules responsible for costimulatoryactivity were not constitutively expressed on the antigen presenting cell(APC) surface. In the present study, we have identified a clonedmacrophage cell line (FLJ2) with inducible APC function. Theunactivated FLJ2 line could not induce T-cell proliferation. FLJ2 couldpresent alloantigen, and stimulate proliferation of either a T-cell clone ornormal resting T cells following activation with IFN y or unexpectedlywith lipopolysaccaride (LPS)-Activated FLJ2 cells could be fixed andAPC function was preserved. The relevant inducible molecules requiredfor APC function appeared distinct from la and IL1. The expression ofICAM-1 and LFA-1 was increased during activation and anti-LFA-1 antibody blocked APC function. This suggests that one important featureof the activation process may be improvement of cellular adhesion.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Immunopharmacology and Immunotoxicology. - 15 : 4 (2008), p. 327-353. -
További szerzők:	Gusella, Luca Longo, Dan L. Birchenall-Roberts, M. Takács László (1955-) Takei, F. Ruscetti, Francis Musiani, P. Durum, Scott K.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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