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001-es BibID:	BIBFORM069315
Első szerző:	Aiello, Francesca B.
Cím:	A role for cytokines in antigen presentation : IL-1 and IL-4 induce accessory functions of antigen-presenting cells / Francesca B. Aiello, Dan L. Longo, Roy Overton, Laszlo Takacs, Scott K. Durum
Dátum:	1990
ISSN:	0022-1767 1550-6606
Megjegyzések:	Fixation of APC with 1-ethyl-3-(3-dimethylamino-propyl)carbodiimide (ECDI) eliminates their ability to stimulate proliferation of alloreactive T cells or the D10 T cell clone, although a partial response, IL-4 production, was measured. However, if APC were activated before fixation, they could be ECDI-fixed and retain the ability to induce T cell proliferation. IL-1, IL-4 or LPS were capable of activating APC in this way, whereas IFN-gamma was not. This activation step occurred in 6 h, required protein synthesis, and was distinct from increases in Ia or IL-1. This suggests resting APC lack structures that are essential for inducing T cell proliferation.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Immunology. - 144 : 7 (1990), p. 2572-2581. -
További szerzők:	Longo, Dan L. Overton, Roy Takács László (1955-) Durum, Scott K.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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