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001-es BibID:	BIBFORM069323
Első szerző:	Takács László
Cím:	IL 1 induction by murine T cell clones : detection of an IL 1-inducing lymphokine / Laszlo Takacs, Jay A. Berzofsky, Jena York-Jolley, Tohru Akahoshi, Elisabetta Blasi, Scott K. Durum
Dátum:	1987
Megjegyzések:	T cell activation is widely believed to depend on interleukin 1 (IL 1) provided by antigen (Ag)-presenting cells (APC). Because IL 1 is not a constitutive product of APC, we examined the features of its production during the interaction of murine T cell clones and APC. We observed that IL 1 was detectable in supernatants of most myoglobin-specific T cell clones grown with APC and Ag. Two of these T cell clones induced exceptionally high levels of IL 1 in their supernatants, and these same clones demonstrated the unusual restriction to I-Ek, which is a low responder type for sperm whale myoglobin. One of these clones was characterized additionally as to the mechanism of IL 1 induction. This clone rapidly stimulated IL 1 production in the APC population (detectable at 4 hr of co-culture) or in macrophages (M phi) or a M phi-like cell line. IL 1 induction was Ag dependent and H-2 restricted. Induction was radioresistant, both on the part of the T cell and of the IL 1 producer. The IL 1-induction process was attributable to a lymphokine produced by the T cell clone. This lymphokine was distinct from IFN-gamma, TNF and CSF-1 and may account for a principal mechanism of T----APC signalling. The induced IL 1 was the same in size, co-mitogenicity, and pyrogenicity as lipopolysaccharide-induced IL 1.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	The Journal of Immunology 138 : 7 (1987), p. 2124-2131. -
További szerzők:	Berzofsky, Jay A. York-Jolley, Jena Akahoshi, Tohru Blasi, Elisabetta Durum, Scott K.
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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