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001-es BibID:	BIBFORM069535
035-os BibID:	(WoS)000405007900001 (Scopus)85026529272
Első szerző:	Orosz Erzsébet (biológus)
Cím:	Transcriptome-based modeling reveals that oxidative stress induces modulation of the AtfA-dependent signaling networks in Aspergillus nidulans / Erzsébet Orosz, Károly Antal, Zoltán Gazdag, Zsuzsa Szabó, Kap-Hoon Han, Jae-Hyuk Yu, István Pócsi, Tamás Emri
Dátum:	2017
ISSN:	2314-436X 2314-4378
Megjegyzések:	To better understand the molecular functions of the master stress-response regulator AtfA inAspergillus nidulans, transcriptomic analyses of the atfA null mutant and the appropriatecontrol strains exposed to menadione sodium bisulfite (MSB), t-butylhydroperoxide and46 diamide induced oxidative stresses were performed. Several elements of oxidative stressresponse were differentially expressed. Many of them, including the down-regulation ofmitotic cell cycle as well as the MSB stress specific up-regulation of FeS cluster assemblyand the MSB stress specific down-regulation of nitrate reduction, tricarboxylic acid cycle aswell as ER to Golgi vesicle-mediated transport showed AtfA-dependence. To elucidate apotential global regulatory role of AtfA governing expression of a high number of genes withvery versatile biological functions, which are stress specific, we devised a model based on the53 comprehensive transcriptomic data. Our model suggests that an important function of AtfA isto modulate the transduction of stress signals. Although it may regulate directly only a limitednumber of genes these include elements of the signaling network, e.g. members of two-component signal transduction systems. AtfA acts in a stress-specific manner, which mayincrease further the number and diversity of AtfA-dependent genes. Our model sheds light onthe versatility of the physiological functions of AtfA and its orthologs in fungi.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Aspergillus nidulans oxidative stress interplay between signaling pathways bZIP-type transcription factors
Megjelenés:	International Journal of Genomics. - 2017 (2017), p. 1-16. -
További szerzők:	Antal Károly (neurobiológus) Gazdag Zoltán Szabó Zsuzsa (1990-) (kémikus) Han, Kap-Hoon Yu Jae-Hyuk Pócsi István (1961-) (vegyész) Emri Tamás (1969-) (biológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat Szerző által megadott URL DOI
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