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001-es BibID:	BIBFORM069727
035-os BibID:	(Scopus)85042480817 (WoS)000419198000001
Első szerző:	Tajti Gábor (gyógyszerész, biofizikus, sejtbiológus)
Cím:	Positive correlation of airway resistance and serum asymmetric dimethylarginine (ADMA) in bronchial asthma patients lacking evidence for systemic inflammation / Gabor Tajti, Csaba Papp, Laszlo Kardos, Sandor Keki, Krisztian Pak, Magdolna Emma Szilasi, Rudolf Gesztelyi, Angela Mikaczo, Andrea Fodor, Maria Szilasi, Judit Zsuga
Dátum:	2018
ISSN:	1710-1484
Megjegyzések:	Background: Contribution of nitric-oxide (NO) pathway to the pathogenesis of bronchial asthma (asthma) is ambiguous as NO may confer both protective and detrimental effects depending on the NO synthase (NOS) isoforms, tissue compartments and underlying pathological conditions (e.g. systemic inflammation). Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor and uncoupler of NOS with distinct selectivity for NOS isoforms. In a cross-sectional study, we assessed whether ADMA is an independent predictor of airway resistance (Raw) in therapy-controlled asthma.Methods: 154 therapy-controlled asthma patients were recruited. ADMA, symmetric dimethylarginine and arginine were quantitated by HPLC with fluorescent detection. Pulmonary function test was done using whole-body plethysmography, quality of life via St. George's Respiratory Questionnaire (SGRQ). Multiple linear regression was used to identify independent determinants of Raw. The final model was stratified based on therapy control.Results: Evidence for systemic inflammation indicated by CRP and procalcitonin was lacking in our sample. Log Raw showed significant positive correlation with log ADMA in the whole data set and well-controlled but not in the not well-controlled stratum (Spearman correlation coefficients: 0.27, p<0.001; 0.30, p<0.001; 0.12, p=0.51 respectively). This relationship remained significant after adjusting for confounders by multiple linear regression (?=0.22, CI: 0.054, 0.383 p=0.01). FEF25-75%% predicted and SGRQ Total score showed significant negative while SGRQ Activity score showed significant positive correlation with Raw in the final model.Conclusions: Positive correlation between Raw and ADMA in the absence of systemic inflammation implies that higher ADMA has detrimental effect on NO homeostasis and can contribute to a poor outcome in asthma.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban ADMA airway resistance bronchial asthma SGRQ whole-body plethysmography
Megjelenés:	Allergy, Asthma and Clinical Immunology. - 14 : 2 (2018), p. 1-12. -
További szerzők:	Papp Csaba (1966-) (aneszteziológus és intenzív terápiás szakorvos) Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Kéki Sándor (1964-) (polimer kémikus) Pák Krisztián (1987-) (gyógyszerész) Szilasi Magdolna Emma (1983-) (pulmonológus) Gesztelyi Rudolf (1969-) (kísérletes farmakológus) Mikáczó Angéla (1980-) (tüdőgyógyász) Fodor Andrea Szilasi Mária (1953-) (tüdőgyógyász, klinikai immunológus, allergológus, belgyógyász) Zsuga Judit (1973-) (neurológus, pszichoterapeuta, egészségügyi szakmanager)
Pályázati támogatás:	KTIA_13_NAP-A-V/2 Egyéb
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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