Találati lista | Tudóstér

001-es BibID:	BIBFORM070058
Első szerző:	Pogácsás Lilla
Cím:	Long-term drug survival and predictor analysis of the whole psoriatic patient population on biological therapy in Hungary / Pogácsás Lilla, Borsi András, Takács Péter, Remenyik Éva, Kemény Lajos V., Kárpáti Sarolta, Holló Péter, Wikonkál Norbert, Gyulai Rolland, Károlyi Zsuzsanna, Rakonczai Pál, Balázs Tamás, Szegedi Andrea
Dátum:	2017
ISSN:	0954-6634 1471-1753
Megjegyzések:	Persistence is an important component of therapeutic success, which depends on a variety of factors.Persistence measured under optimal conditions during clinical trials does not necessarily coincide withpersistence observed in the real-world settings. The aim of the present study was to compare persistencerate of TNF-alpha inhibitors and interleukin 12/23 inhibitor in all psoriasis patients in Hungary, as well asto analyze the predictors of persistence. Data collected from 1263 patients over a period of 46monthswere subjected to a retrospective analysis. Drug survival rate has been calculated according toKaplan?Meier analysis and Cox regression was used to study the predictors. The overall persistence ratefor the four biologicals exceeded 60% after 3 years. The persistence rate of ustekinumab at 3 years was67.83%, which was superior compared to that of the TNF-alpha inhibitors, where the mean persistencerate was shown to be 50.76% (p<.05). Male patients showed significantly higher persistence than females(HR?.76, p<.05 CI: 0.63, 0.92). Age, therapy-naïve status and use of concomitant MTX did not havesignificant effect on drug survival. Persistence rate of ustekinumab was significantly higher than that ofTNF-alpha inhibitors, and among predictors, only male gender influenced persistence significantly.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Biological therapy comparison hazard ratios persistence predictors psoriasis
Megjelenés:	Journal of Dermatological Treatment 28 : 7 (2017), p. 635-641. -
További szerzők:	Borsi András Takács Péter Remenyik Éva (1956-) (bőrgyógyász) Kemény Lajos V. (bőrgyógyász Szeged) Kárpáti Sarolta Holló Péter Wikonkál Norbert (1968-) (bőrgyógyász) Gyulai Rolland Károlyi Zsuzsánna Rakonczai Pál Balázs Tamás Szegedi Andrea (1964-) (bőrgyógyász)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: