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001-es BibID:BIBFORM070460
Első szerző:Pozsgay Judit
Cím:Antigen-specific immunotherapies in rheumatic diseases / Pozsgay Judit, Szekanecz Zoltán, Sármay Gabriella
Dátum:2017
ISSN:1759-4790 1759-4804
Megjegyzések:The main goal of antigen-specific immunotherapy (ASI) [Au:OK?] in autoimmune andrheumatic diseases is to reprogramme or remove autoreactive cells and/or induce immunetolerance to self-antigens. Current therapies in these diseases either treat symptoms or slowdown disease progression but are not yet curative or preventative ? disease-specific treatmentsare urgently needed. In contrast to the nonspecific treatments in current use that inducegeneralized immune suppression, which is associated with several adverse effects includingincreased risk of infections, ASIs target a restricted subset of B cells or T cells, and thus do notcompromise systemic immunity and host defence. This Review provides a summary of novelapproaches for identifying autoepitopes and detecting and targeting autoreactive cells thatmight help in the development of ASIs. Promising approaches include the use of tolerizingpeptides coupled to MHC constructs and/or nanocompounds[Au:OK?], tolerizing dendritic cellsand antigen-specific vaccines. Following studies in animal models of rheumatoid arthritis andsystemic lupus erythematosus, several of these strategies have now entered clinical trials.However, to use these approaches in humans, several important limitations must first beaddressed, such as; selecting the proper immunodominant autoantigen; identifying the optimaltiming, dosing and route of administration; finding biomarkers for monitoring the therapy; andoptimizing methodology [Au:OK?].
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Nature Reviews Rheumatology 13 : 9 (2017), p. 525-537. -
További szerzők:Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Sármay Gabriella
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