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001-es BibID:	BIBFORM070473
035-os BibID:	(WoS)000385353200010 (Scopus)84983551225
Első szerző:	Oláh Attila (élettanász)
Cím:	Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatment / Oláh Attila, Markovics Arnold, Szabó-Papp Judit, Szabó Pálma Tímea, Stott Colin, Zouboulis Christos C., Bíró Tamás
Dátum:	2016
ISSN:	0906-6705
Megjegyzések:	Acne is a common skin disease characterized by elevatedsebum production and inflammation of the sebaceous glands. Wehave previously shown that a non-psychotropic phytocannabinoid((?)-cannabidiol [CBD]) exerted complex anti-acne effects bynormalizing ♭pro-acne agents'-induced excessive sebaceous lipidproduction, reducing proliferation and alleviating inflammation inhuman SZ95 sebocytes. Therefore, in this study we aimed to explorethe putative anti-acne effects of further non-psychotropic phytocannabinoids((?)-cannabichromene [CBC], (?)-cannabidivarin[CBDV], (?)-cannabigerol [CBG], (?)-cannabigerovarin [CBGV]and (?)-D9-tetrahydrocannabivarin [THCV]). Viability andproliferation of human SZ95 sebocytes were investigated by MTTand CyQUANT assays; cell death and lipid synthesis weremonitored by DilC1(5)-SYTOX Green labelling and Nile Redstaining, respectively. Inflammatory responses were investigated bymonitoring expressions of selected cytokines uponlipopolysaccharide treatment (RT-qPCR, ELISA). Up to 10 lM, thephytocannabinoids only negligibly altered the viability of thesebocytes, whereas high doses (?50 lM) induced apoptosis.Interestingly, basal sebaceous lipid synthesis was differentiallymodulated by the substances: CBC and THCV suppressed it, andCBDV had only minor effects, whereas CBG and CBGV increased it.Importantly, CBC, CBDV and THCV significantly reducedarachidonic acid (AA)-induced ♭acne-like' lipogenesis. Moreover,THCV suppressed proliferation, and all phytocannabinoids exertedremarkable anti-inflammatory actions. Our data suggest that CBGand CBGV may have potential in the treatment of dry-skinsyndrome, whereas CBC, CBDV and especially THCV showpromise to become highly efficient, novel anti-acne agents.Moreover, based on their remarkable anti-inflammatory actions,phytocannabinoids could be efficient, yet safe novel tools in themanagement of cutaneous inflammations.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk acne vulgaris cutaneous inflammation dry skin phytocannabinoid
Megjelenés:	Experimental Dermatology. - 25 : 9 (2016), p. 701-707. -
További szerzők:	Markovics Arnold (1988-) (molekuláris biológus) Papp Judit (élettanász) Szabó Pálma Stott, Colin Zouboulis, Christos C. (1960-) (bőrgyógyász) Bíró Tamás (1968-) (élettanász)
Pályázati támogatás:	Lendület LP2011-003/ 2015 Egyéb TÁMOP-4.2.4.A/2-11-1-2012-0001 TÁMOP OTKA 101761 Egyéb OTKA 105368 Egyéb TÁMOP-4.2.2-08/1/2008-0019 Egyéb FP7-REGPOT-2008-1/229920 Egyéb
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