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001-es BibID:	BIBFORM070612
035-os BibID:	(WoS)000416505400018 (Scopus)85028574106
Első szerző:	Mezei Zoltán András (orvos)
Cím:	Factor XIII levels and factor XIII B subunit polymorphisms in patients with venous thromboembolism / Zoltán A. Mezei, Éva Katona, Judit Kállai, Zsuzsanna Bereczky, Laura Somodi, Éva Molnár, Bettina Kovács, Tünde Miklós, Éva Ajzner, László Muszbek
Dátum:	2017
ISSN:	0049-3848
Megjegyzések:	Background: The association of plasma factor XIII (FXIII) level with venous thromboembolism (VTE) is still controversial and the effect of sex and FXIII B subunit (FXIII-B) polymorphisms in this respect have not been explored.Objectives: 1/ To determine FXIII activity and antigen levels in patients with a history of VTE and how they are influenced by sex and FXIII-B polymorphisms. 2/ To explore the association of FXIII levels and FXIII-B polymorphisms with the risk of VTE.Methods: 218 VTE patients and equal number of age and sex matched controls were enrolled in the study. FXIII activity was measured by ammonia release assay; FXIII-A2B2 and FXIII-B levels were determined by ELISAs. FXIII-B polymorphisms were identified by RT-PCR using melting point analysis.Results: Adjusted FXIII activity and FXIII-A2B2 antigen levels were significantly higher in females with a history of VTE than in the respective controls. FXIII-B levels were significantly lower in male VTE patients than in controls. FXIII-A2B2 antigen levels in the upper tertile increased the risk of VTE in females (adjusted OR: 2.52; CI:1.18?5.38). Elevated FXIII-B antigen level had a protective effect only in males (adjusted OR: 0.19; CI:0.08?0.46). FXIII-B Intron K c.1952+144 C > G polymorphism significantly lowered FXIII activity, FXIII-A2B2 and FXIII-B antigen levels in both groups. FXIII-B polymorphisms did not influence the risk of VTE.Conclusions: In VTE patients the changes of FXIII level and their effect on the risk of VTE show considerable sexspecific differences. Intron K polymorphism results in decreased FXIII levels, but does not influence the risk of VTE.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Factor XIII Factor XIII-B subunit Polymorphisms Venous thromboembolism
Megjelenés:	Thrombosis Research. - 158 (2017), p. 93-97. -
További szerzők:	Katona Éva (1961-) (klinikai biokémikus) Kállai Judit (1983-) (molekuláris biológus) Bereczky Zsuzsanna (1974-) (orvosi laboratóriumi diagnosztika szakorvos) Somodi Laura (1991-) (klinikai laboratóriumi kutató) Molnár Éva (1977-) (analitikus) Kovács Bettina (1975-) (orvos) Miklós Tünde Ajzner Éva (1968-) (laboratóriumi szakorvos) Muszbek László (1942-) (haematológus, kutató orvos)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00050 GINOP K113097 OTKA K116228 OTKA K120633 OTKA MTA 11003 TKI417 Egyéb
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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