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001-es BibID:	BIBFORM070644
035-os BibID:	(WOS)000456915500003 (Scopus)85029807859
Első szerző:	Nagy Ádám
Cím:	Molecular Subgroups of Glioblastoma : an Assessment by Immunohistochemical Markers / Nagy Ádám, Garzuly Ferenc, Padányi Gergely, Szűcs Iván, Feldmann Ádám, Murnyák Balázs, Hortobágyi Tibor, Kálmán Bernadette
Dátum:	2019
ISSN:	1219-4956
Megjegyzések:	Comprehensive molecular characterization of and novel therapeutic approaches to glioblastoma have been explored as a result of advancements in biotechnologies. In this study, we aimed to bring basic research discoveries closer to clinical practice and ultimately incorporate molecular classification into the routine histopathological evaluation of grade IV gliomas. Integrated results of genome-wide sequencing, transcriptomic and epigenomic analyses by The Cancer Genome Atlas Network defined the classic, proneural, neural and mesenchymal subtypes of this tumor. In a retrospective cohort, we analyzed selected subgroup-defining molecular markers in formalin-fixed paraffin-embedded surgical specimens by immunohistochemistry. Quantitative and qualitative scores of marker expression were tested in hierarchical cluster analyses to evaluate segregations of the molecular subgroups, which then were correlated with clinical parameters including patients' age, gender and overall survival. Our study has confirmed the separation of molecular glioblastoma subgroups with clear trends regarding clinical correlations. Future analyses in a larger, prospective cohort using similar methods are expected to facilitate the development of a molecular diagnostic panel that may complement routine histological work up and support prognostication as well as treatment decisions in glioblastoma.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Glioblastoma Molecular subgroups Translation Clinical setting
Megjelenés:	Pathology & Oncology Research. - 25 : 1 (2019), p. 21-31. -
További szerzők:	Garzuly Ferenc (1937-) (neurológus) Padányi Gergely Szűcs Iván Feldmann Ádám Murnyák Balázs (1986-) (molekuláris biológus, genetikus) Hortobágyi Tibor (1965-) (patológus) Kálmán Bernadette
Pályázati támogatás:	NAP KTIA_13_NAP-A-II/7 KTIA GINOP-2.3.2-15-2016-00043 GINOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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