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001-es BibID:	BIBFORM070757
Első szerző:	Frendl István (baleseti sebész és kézsebész)
Cím:	Plasminogen Activator Inhibitor Type 1 : a Possible Novel Biomarker of Late Pituitary Dysfunction after Mild Traumatic Brain Injury / Istvan Frendl, Monika Katko, Erika Galgoczi, Judit Boda, Noemi Zsiros, Zoltan Nemeti, Zsuzsanna Bereczky, Renata Hudak, Janos Kappelmayer, Annamaria Erdei, Bela Turchanyi, Endre V. Nagy
Dátum:	2017
ISSN:	0897-7151
Megjegyzések:	More than 80% of head trauma patients suffer from mild traumatic brain injury (mTBI). However, even mTBI carries the risk of late pituitary dysfunction. A predictive biomarker at the time of injury which could identify patients who subsequently may develop permanent pituitary dysfunction would help to direct patients towards endocrine care. We enrolled 508 traumatic brain injury patients (406 with mTBI) into our study. Blood samples were collected for identification of predictive biomarkers of late pituitary dysfunction at the time of admission. Follow-up blood samples were collected between 6 to 12 months after the head trauma and were evaluated for pituitary function. Of the 406 mTBI patients, 76 were available for follow-up. Pre-existing mild pituitary dysfunction was found for 15 patients based on hormone levels at the time of injury. Of the remaining 61 patients, 10 have shown deficiency in at least one pituitary hormone: 4 had growth hormone deficiency, 3 gonadotropin, 2 thyrotropin, and 1 patient combined gonadotropin and thyrotropin deficiency. Hence, newly developed pituitary hormone deficiency was found in 16% of mTBI patients. Neither the cause of mTBI nor its complications were predictive of late pituitary dysfunction. Of the haemostasis parameters studied, lower PAI-1 level at the time of injury was found to be predictive for the development of late pituitary dysfunction; sensitivity, specificity, positive and negative predictive values were 80%, 67%, 32% and 94%, respectively. Even mild TBI carries a substantial risk of endocrine consequences. Serum PAI-1 level at the time of head trauma may serve as predictive biomarker of late pituitary dysfunction in mTBI patients.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal Of Neurotrauma. - 34 : 23 (2017), p. 3238-3244. -
További szerzők:	Katkó Mónika (1980-) (biológus) Galgóczi Erika (1986-) (biológus) Boda Judit (belgyógyász, endokrinológus) Zsíros Noémi (1986-) (belgyógyász) Németi Zoltán Bereczky Zsuzsanna (1974-) (orvosi laboratóriumi diagnosztika szakorvos) Hudák Renáta Kappelmayer János (1960-) (laboratóriumi szakorvos) Erdei Annamária (1976-) (belgyógyász) Turchányi Béla (1957-) (traumatológus) Nagy Endre V. (1957-) (belgyógyász, endokrinológus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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